Postdoctoral Position in Cell Biology (F/M) (F/H)

PSL Université Paris; Paris; Hybride; EUR 31 000 - 37 000; Plein temps

Avantages offerts par ce poste

Collective catering

Transport reimbursement

Supplementary health insurance

Résumé du poste

Institut Curie in Paris invites applications for a Postdoctoral Position in Cell Biology (F/M) in the Membrane Mechanics and Dynamics of Intracellular Signaling lab. The project investigates IFN-γR signaling and lipid nanodomains at the plasma membrane using advanced imaging and biochemical approaches.

Candidates hold a PhD in cell biology or biophysics, have experience in advanced microscopy and membrane biology, and can communicate in English.

Qualifications

• PhD in cell biology or biophysics with publications in these fields.
• Experience in advanced microscopy, membrane biology, and 3D model systems.
• Up to four years of post-PhD experience.
• Strong English communication skills.
• Ability to work independently and in a team.
• High integrity and rigor.

Responsabilités

• Investigate IFN-γR signaling and lipid nanodomains at the plasma membrane.
• Combine biochemistry and biophysics approaches to mechanobiology research.
• Employ advanced imaging to study membrane dynamics under mechanical cues.
• Collaborate with French academic partners.

Connaissances

Advanced microscopy

Membrane biology

3D model systems

Surface functionalization

English communication

Formation

PhD in cell biology or biophysics

Postdoc experience

Description du poste

Postdoctoral Position in Cell Biology (F/M) (F/H)

The Curie Institute Research Center

The Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international representativeness. The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Missions

Laboratory

The host laboratory, Membrane Mechanics and Dynamics of Intracellular Signaling, led by Dr Christophe Lamaze is part of the Chemical Biology of Cancer (UMR3666 CNRS-U1339 INSERM). The team research focuses on understanding how plasma membrane dynamics and trafficking control the signal transduction, in particular during mechanical stress. In the lab, Dr Cedric Blouin has developed an original line of research combining biochemistry and biophysics to investigate mechanobiology and lipid nanodomains in JAK/STAT signaling.

The interplay between plasma membrane lipids, membrane associated proteins, the actin cytoskeleton and dynamic scaffolding structures such as clathrin-coated assemblies and caveolae is still poorly understood. Deciphering how the dynamics and the nanoscale organization of the plasma membrane control cell signaling remains a major challenge in cell biology. Based on our previous work (Blouin et al. Cell 2016; Li et al. BioRxiv; Mani et al., Nat Cell Biol 2026), the project aims to determine how the IFN-γR signaling receptor dynamically interacts with lipid nanodomains at the plasma membrane, how it connects with the various molecular assemblies beneath, and how these interactions are tuned by mechanical cues. To elucidate the molecular mechanisms that control IFN-γR signaling, we will a unique combination of advanced imaging techniques upon control of membrane architecture and mechanical status. Building on recent C. Blouin’s ANR grant, the project will benefit from a well-equipped and strongly supported research environment, providing excellent conditions for ambitious research and will additionally involve French academic partners.

Training and Skills required

• PhD in cell biology or biophysics with publications in these fields
• Scientific skills: prior experience in advanced microscopy, membrane biology, 3D model systems will be preferred. Knowledge in surface and matrix functionalization would be appreciated
• Professional experience desirable: up to four year after PhD
• Language skills: strong communication skills in English
• Strong motivation and ability to work independently, creativity and interest in interdisciplinary research
• Aptitude for working and integrating in a team
• Ability to communicate
• High level of integrity and rigor

All our opportunities are open to people with disabilities

Contract information

Type of contract: Fixed-term contract.

Starting date:early January at the latest

Duration: 2 years

Working time: full time

Remuneration: 3018.26 €/month, according to the current grids

Benefits:

• Collective catering
• reimbursement of transportation fees up to 70%
• supplementary health insurance

Location of the position: Paris

Deadline for application: end of September

Faithful to the legacy of its founder, the Institut Curie is deeply committed to promoting equal opportunities, diversity, and inclusion. Convinced that diversity of backgrounds and experiences contributes to collective performance, we strive to provide everyone with a respectful and equitable working environment and encourage all candidates to apply for our job opportunities.