Postdoctoral fellow in Cytokine induced cell death

Servier; Palaiseau; À distance; EUR 42 000 - 54 000; Plein temps

Avantages offerts par ce poste

13th month salary

Profit-sharing / employee participate.

Transportation allowance

27 days paid leave + 23 RTT

Flexible remote work options depending

On-site restaurant and CSE activities

Résumé du poste

Servier invites applications for a three-year Postdoctoral fellow in Cytokine induced cell death at the Paris-Saclay R&D Institute. The project explores How colorectal cancer cells resist immune cytokine pressure and aims to enhance cytokine-induced tumor-cell killing using mechanistic biology, functional genomics and translational models.

The candidate will work in a collaborative, multi-disciplinary team, applying cutting-edge techniques in cell biology and translational cancer research to

Qualifications

• PhD in cancer biology, tumor immunology, cell-death biology, molecular biology, functional genomics or a related discipline.
• Experience with oncology models and/or cytokine signaling is an advantage.
• Expertise in mammalian cell culture and quantitative cell-based assays.
• Experience with cancer cell models and with one or more of the following: CRISPR-based perturbation or screening, flow cytometry, immunoblotting, or analysis of signaling and cell-death pathways.
• Experience with organoids or patient-derived models is a plus.
• Excellent written and oral English.
• Ability to drive a research project with scientific independence, organize priorities, collaborate effectively in multidisciplinary teams, and communicate results clearly to scientific and project stakeholders.
• Autonomous, proactive, rigorous, collaborative and innovative.

Responsabilités

• Design and execute in vitro and in vivo experiments to advance the research project.
• Analyze and interpret data and define next steps.
• Review literature and integrate findings into decisions.
• Present progress at internal meetings.
• Manage priorities, timelines and resources for project execution.
• Collaborate across Immuno-Oncology programs and share learnings.
• Identify and evaluate potential therapeutic targets.

Connaissances

PhD in cancer biology

Cytokine signaling

Mammalian cell culture

CRISPR perturbation

Flow cytometry

Immunoblotting

Organoid models

English proficiency

Formation

PhD in cancer biology or related

Outils

CRISPR-based perturbation

Description du poste

Postdoctoral fellow in Cytokine induced cell death

We are a global and independent mid-sized pharmaceutical group governed by a Foundation. Our unique model makes us proud and, more importantly, enables us to fully serve our mission: "committed to therapeutic progress for the benefit of patients."

As a global leader in cardiology, we aim to become a focused and innovative player in oncology by 2030, targeting hard-to-treat cancers and dedicating more than 70% of our R&D budget to this goal.

Who are we? 20,000 passionate individuals from over 50 nationalities, driven by an entrepreneurial spirit. Every day, we move forward with and for patients, with and for our teams, motivated by the desire to care, to dare, to grow, and to commit to being useful to those in need.

Come and experience and contribute to our commitment #MovedByYou.

At the heart of one of the world's top eight innovation clusters, the Servier R&D Institute at Paris-Saclay is where visionary science meets a powerful global ecosystem. By uniting our Group's innovation potential with this prestigious center of excellence, we are not only accelerating the future of therapeutic discovery but also championing the global influence of French research.

This three-year postdoctoral position will investigate the mechanisms by which colorectal cancer cells resist immune cytokine pressure and identify approaches to enhance cytokine-induced tumor-cell killing. The project combines mechanistic biology, functional genomics and translational cancer models to characterize sensitivity and resistance mechanisms in IFN/TNF signaling and cell-death pathways, and to generate therapeutic and biomarker hypotheses with translational potential.

Main responsibilities

1. Design and execute relevant in vitro and in vivo experiments to advance the research project.
2. Analyze and interpret experimental data and recommend appropriate next steps.
3. Review scientific literature and integrate relevant findings into project decisions.
4. Present project progress and data in internal scientific and project meetings.
5. Manage priorities, timelines and resources to support efficient project execution.
6. Contribute to collaborative projects within the Immuno-Oncology portfolio and share learnings across programs.
7. Contribute to the identification and evaluation of potential therapeutic targets.

Profile

• PhD in cancer biology, tumor immunology, cell-death biology, molecular biology, functional genomics or a related discipline.
• Experience with oncology models and/or cytokine signaling is an advantage.
• Expertise in mammalian cell culture and quantitative cell-based assays.
• Experience with cancer cell models and with one or more of the following: CRISPR-based perturbation or screening, flow cytometry, immunoblotting, or analysis of signaling and cell-death pathways.
• Experience with organoids or patient-derived models is a plus.
• Excellent written and oral English.
• Ability to drive a research project with scientific independence, organize priorities, collaborate effectively in multidisciplinary teams, and communicate results clearly to scientific and project stakeholders.
• Autonomous, proactive, rigorous, collaborative and innovative.

Our standard recruitment journey includes the following steps:

• Prequalification Interview
• Interview with the Manager
• Interview with Talent Acquisition Team / Human Resources
• Reference Check Process

At one stage of the process, we would be delighted to welcome you to our site to meet in person and share the environment where we work every day to transform patients' lives!

Please note that this recruitment process may be adapted based on the specific requirements of the position.

• 13th-month salary, contribution to results bonus, profit-sharing / employee participation, and transportation allowance
• 27 days of paid leave, plus 23 RTT days (reduced working hours)
• Flexible remote work options depending on the role
• On-site company restaurant, and a wide range of employee committee (CSE) activities and associations

We are committed to equal opportunities and developing talents in all their diversity. We value both experience and the desire to engage daily in contributing to therapeutic progress for the benefit of patients. If this offer resonates with you, seize this opportunity to meet us!