Postdoc: KCC2 Imaging & Neuronal Electrophysiology

CNRS; France; On-site; EUR 35,000 - 45,000; Full time

Job summary

CNRS, La Synapse Dynamique team at ESPCI Paris, seeks a researcher to investigate the effects of artificial KCC2 clustering on chloride regulation in hippocampal neurons. The project combines super-resolution imaging, single-molecule tracking, and electrophysiology in mouse and human tissue.

The successful candidate will work within the Brain Plasticity Unit (UMR 8239) and contribute to understanding GABAergic synapse plasticity, membrane dynamics, and activity patterns in epileptic tissue.

Qualifications

• Experience with electrophysiology techniques (patch-clamp) and single-molecule imaging is essential.
• Strong background in neurobiology and imaging modalities (STORM/PALM) is required.
• Ability to work autonomously and communicate results regularly to the team.

Responsibilities

• Develop super-resolution imaging and single-molecule tracking of KCC2 in interneurons and pyramidal cells.
• Characterize membrane distribution and mobility of KCC2 across neuron types in mouse and human tissue.
• Perform electrophysiology recordings (patch-clamp EGABA, MEA) in human epileptic tissue slices.

Skills

Neurosciences

Electrophysiology

Super-resolution imaging

Autonomy

Team collaboration

Progress reporting

Job description

CNRS, La Synapse Dynamique team at ESPCI Paris, seeks a researcher to investigate the effects of artificial KCC2 clustering on chloride regulation in hippocampal neurons. The project combines super-resolution imaging, single-molecule tracking, and electrophysiology in mouse and human tissue.

The successful candidate will work within the Brain Plasticity Unit (UMR 8239) and contribute to understanding GABAergic synapse plasticity, membrane dynamics, and activity patterns in epileptic tissue.