Post-doctoral training in Epigenetics (M/F)

CNRS - National Center for Scientific Research; France; On-site; EUR 28,000 - 34,000; Full time

Job summary

CNRS, Institute Curie – Research Center, UMR3244 Dynamics of Genetic Information: Fundamental Bases and Cancer, invites applications for a First Stage Researcher (R1) position focusing on the regulation of X-chromosome gene expression during human brain development. The project combines bioinformatics analyses with stem cell biology to differentiate human pluripotent stem cells into brain organoids.

Responsibilities include scRNA-seq data generation/analysis, RNA-FISH on organoid sections, and

Qualifications

• Finalization of a research project focusing on the regulation of X-chromosome gene expression during human brain development.
• Bioinformatics analyses are required for data interpretation.
• Culture of human pluripotent stem cells for organoid formation.
• Differentiation of human pluripotent stem cells into human brain organoids.
• Oral presentations in English are expected.

Responsibilities

• Differentiation of human pluripotent stem cells into human brain organoids.
• IF and RNA-FISH on brain organoid sections.
• Generation and analysis of scRNA-seq data.
• Allelic analysis of RNA-seq data.
• Presentation of results in English.
• Writing of scientific articles in English.

Skills

Bioinformatics analyses

Oral presentations in English

Tools

RNA-FISH

scRNA-seq data analysis

Job description

Organisation/Company CNRS Department Dynamique de l'information génétique : bases fondamentales et cancer Research Field Biological sciences Researcher Profile First Stage Researcher (R1) Application Deadline 24 Nov 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 4 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Finalization of a research project focusing on the regulation of X-chromosome gene expression during human brain development

• Bioinformatics analyses
• Culture of human pluripotent stem cells
• Differentiation of human pluripotent stem cells into human brain organoids
• Oral presentations in English

Institut Curie – Research Center
UMR3244 – Dynamics of Genetic Information: Fundamental Bases and Cancer
Laboratory: Sex Chromosomes, Development, and Diseases (Dr. Claire Rougeulle)

• Differentiation of human pluripotent stem cells into human brain organoids
• IF and RNA-FISH on brain organoid sections
• Generation and analysis of scRNA-seq data
• Allelic analysis of RNA-seq data
• Presentation of results in English
• Writing of scientific articles in English