Chromosome Biology Post-doc position (F/M)

Institut Curie - Research Center; France; On-site; EUR 36,000 - 40,000; Full time

Benefits offered by this job

Catering service

Transportation reimbursement 75%

Supplementary health insurance

Job summary

The Curie Institute's Research Center in Paris invites applications for a 12‑month, full‑time Postdoc position within the ERC GeneMotors program. You will join Leonid Mirny's team, bridging theory, computation and experiment to study cohesin-mediated genome folding and enhancer–promoter regulation.

We seek a PhD in Biology, Physics or Biophysics with a strong background in chromosome biology, Hi-C and quantitative data analysis.

Qualifications

• PhD in Biology, Physics or Biophysics required.
• Fluency in English; English is the working language.
• Experience with Hi-C and other genomic techniques.
• Ability to work independently and collaborate across disciplines.
• Strong data analysis and modeling skills.

Responsibilities

• Develops and validates quantitative models of genome regulation.
• Perform experimental tests of centromere organization and DNA repair.
• Analyze Hi-C, genomic and imaging data to test models.
• Collaborate with computational and experimental teams.
• Contribute to publications and presentations.

Skills

Chromosome biology

Quantitative data analysis

Modeling & interdisciplinary work

Independent work

Education

PhD in Biology, Physics or Biophysics

Tools

Hi-C

Super-resolution microscopy

Genomic data analysis

Job description

Organisation/Company Institut Curie - Research Center Department Administration Research Field Medical sciences » Cancer research Researcher Profile First Stage Researcher (R1) Positions Postdoc Positions Application Deadline 7 Dec 2026 - 00:00 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Offer Starting Date 6 Nov 2026 Is the job funded through the EU Research Framework Programme? Horizon Europe - ERC Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The hosting structure

The Curie Institute Research Center

France's leading cancer research and treatment centre, Institut Curie unites a renowned research centre and a specialist hospital, fostering close collaboration between scientists, clinicians and healthcare professionals. It offers an environment of excellence where expertise comes together around shared values: care, humanity, openness, collaboration, efficiency, innovation, solidarity and commitment.

Context

The laboratory

The successful candidate will join the team led by Leonid Mirny at Institut Curie, affiliated with both Institut Curie UMR 3664 (Paris) and the Massachusetts Institute of Technology (MIT) for ERC GeneMotors Program.

The team studies the physical principles of genome organization and their impact on cellular function, combining theoretical modeling, computational approaches, and close interaction with experimental collaborators.

A large part of our current research focuses on understanding how cohesin-mediated loop extrusion and chromatin folding regulate enhancer-promoter communication.

The project

This position is part of a newly funded ERC-supported project aimed at understanding the mechanistic principles by which cohesin-mediated loop extrusion controls long-range gene regulation and other chromosome function.

The candidate will play a central role in developing and validating quantitative models of genome regulation within the GeneMotors program. The position involves experimental testing of models of centromere organization and DNA repair via SMC-mediated loop extrusion dynamics.

Responsibilities include:

• Developsister-resolved Hi-C protocols and obtain Hi-C data for centromeres
• Obtain super-resolution microscopy data of centromere organization and chromosome translocations
• Quantitatively analyze genomic, Hi-C, and imaging data to test models of centromere and chromosome organization.
• Work in close interaction with computational and experimental collaborators to iteratively refine physical predictions
• Contribute to scientific publications and presentations within an international collaborative consortium
  

Candidate Profile

Education and competences

• PhD in Biology, Physics or Biophysics.
• Fluency in English required (English is the working language of the team)

Skills and profile

• Solid background in chromosome biology
• Extensive experience in Hi-C and other genomic techniques
• Experience in quantitative analysis of biological datasets (genomics, transcription, or imaging data)
• Ability to work independently while engaging actively in interdisciplinary collaboration
• Ability to bridge modeling and experimental data in an iterative, hypothesis-driven framework

Contract information

Type of contract: Fixed-term contract.

Duration: 12 months

Working time: full time

Gross annual salary : from 36219€ to 39808€ according to the current grids

• Collective catering
• reimbursement of transportation fees up to 75%
• supplementary health insurance

Location of the position: Paris

Faithful to the legacy of its founder, the Institut Curie is deeply committed to promoting equal opportunities, diversity, and inclusion. Convinced that diversity of backgrounds and experiences contributes to collective performance, we strive to provide everyone with a respectful and equitable working environment and encourage all candidates to apply for our job opportunities.

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