Epigenetics Postdoc: X-Chromosome in Brain Organoids

CNRS - National Center for Scientific Research; France; On-site; EUR 28,000 - 34,000; Full time

Job summary

CNRS, Institute Curie – Research Center, UMR3244 Dynamics of Genetic Information: Fundamental Bases and Cancer, invites applications for a First Stage Researcher (R1) position focusing on the regulation of X-chromosome gene expression during human brain development. The project combines bioinformatics analyses with stem cell biology to differentiate human pluripotent stem cells into brain organoids.

Responsibilities include scRNA-seq data generation/analysis, RNA-FISH on organoid sections, and

Qualifications

• Finalization of a research project focusing on the regulation of X-chromosome gene expression during human brain development.
• Bioinformatics analyses are required for data interpretation.
• Culture of human pluripotent stem cells for organoid formation.
• Differentiation of human pluripotent stem cells into human brain organoids.
• Oral presentations in English are expected.

Responsibilities

• Differentiation of human pluripotent stem cells into human brain organoids.
• IF and RNA-FISH on brain organoid sections.
• Generation and analysis of scRNA-seq data.
• Allelic analysis of RNA-seq data.
• Presentation of results in English.
• Writing of scientific articles in English.

Skills

Bioinformatics analyses

Oral presentations in English

Tools

RNA-FISH

scRNA-seq data analysis

Job description

CNRS, Institute Curie – Research Center, UMR3244 Dynamics of Genetic Information: Fundamental Bases and Cancer, invites applications for a First Stage Researcher (R1) position focusing on the regulation of X-chromosome gene expression during human brain development. The project combines bioinformatics analyses with stem cell biology to differentiate human pluripotent stem cells into brain organoids.

Responsibilities include scRNA-seq data generation/analysis, RNA-FISH on organoid sections, and