Chromosome Biology Post-doc position (F/M) (F/H)

PSL Research University; Paris; On-site; EUR 36,000 - 40,000; Full time

Benefits offered by this job

Collective catering

75% transportation reimbursement

Supplementary health insurance

Job summary

The Curie Institute Research Center in Paris seeks a highly motivated researcher to join the GeneMotors program. You will develop quantitative models of genome regulation and test them with experimental data, focusing on cohesin-mediated loop extrusion and long-range gene regulation.

The role involves close collaboration with computational and experimental teams, contributing to publications, and working in an international environment. A fixed-term, full-time contract is offered in Paris.

Qualifications

• PhD in Biology, Physics or Biophysics.
• Fluency in English required (English is the working language of the team).
• Experience with quantitative analyses of biological datasets (genomics, transcription, or imaging).

Responsibilities

• Develop sister-resolved Hi‑C protocols and obtain Hi‑C data for centromeres.
• Obtain super-resolution microscopy data of centromere organization and chromosome translocations.
• Quantitatively analyze genomic, Hi‑C, and imaging data to test models of centromere and chromosome organization.
• Work with computational and experimental collaborators to iteratively refine physical predictions.
• Contribute to scientific publications and presentations within an international consortium.

Skills

Chromosome biology

Hi-C techniques

Genomic data analysis

Interdisciplinary collaboration

Education

PhD in Biology/Physics/Biophysics

Bac+6 et plus

Job description

The Curie Institute Research Center

France’s leading cancer research and treatment centre, Institut Curie unites a renowned research centre and a specialist hospital, fostering close collaboration between scientists, clinicians and healthcare professionals. It offers an environment of excellence where expertise comes together around shared values: care, humanity, openness, collaboration, efficiency, innovation, solidarity and commitment.

Structure d'accueil

France’s leading cancer research and treatment centre, Institut Curie unites a renowned research centre and a specialist hospital, fostering close collaboration between scientists, clinicians and healthcare professionals. It offers an environment of excellence where expertise comes together around shared values: care, humanity, openness, collaboration, efficiency, innovation, solidarity and commitment.

The laboratory

The successful candidate will join the team led by Leonid Mirny at Institut Curie, affiliated with both Institut Curie UMR 3664 (Paris) and the Massachusetts Institute of Technology (MIT) for ERC GeneMotors Program. The team studies the physical principles of genome organization and their impact on cellular function, combining theoretical modeling, computational approaches, and close interaction with experimental collaborators. A large part of our current research focuses on understanding how cohesin‑mediated loop extrusion and chromatin folding regulate enhancer–promoter communication.

The project

This position is part of a newly funded ERC‑supported project aimed at understanding the mechanistic principles by which cohesin‑mediated loop extrusion controls long‑range gene regulation and other chromosome function.

Expectations / Role

The candidate will play a central role in developing and validating quantitative models of genome regulation within the GeneMotors program. The position involves experimental testing of models of centromere organization and DNA repair via SMC‑mediated loop extrusion dynamics.

Responsibilities Include

• Develop sister‑resolved Hi‑C protocols and obtain Hi‑C data for centromeres
• Obtain super‑resolution microscopy data of centromere organization and chromosome translocations
• Quantitatively analyze genomic, Hi‑C, and imaging data to test models of centromere and chromosome organization.
• Work in close interaction with computational and experimental collaborators to iteratively refine physical predictions
• Contribute to scientific publications and presentations within an international collaborative consortium

Education and competences

• PhD in Biology, Physics or Biophysics.
• Fluency in English required (English is the working language of the team)

Skills And Profile

• Solid background in chromosome biology
• Extensive experience in Hi‑C and other genomic techniques
• Experience in quantitative analysis of biological datasets (genomics, transcription, or imaging data)
• Ability to work independently while engaging actively in interdisciplinary collaboration
• Ability to bridge modeling and experimental data in an iterative, hypothesis‑driven framework

Contract information

Type of contract: Fixed‑term contract.

Starting date: Position available immediately

Duration: 12 months

Working time: full time

Gross annual salary: from 36219€ to 39808€ according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 75%, supplementary health insurance

Location of the position: Paris

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf

Faithful to the legacy of its founder, the Institut Curie is deeply committed to promoting equal opportunities, diversity, and inclusion. Convinced that diversity of backgrounds and experiences contributes to collective performance, we strive to provide everyone with a respectful and equitable working environment and encourage all candidates to apply for our job opportunities.

All our opportunities are open to people with disabilities

Diplôme et expérience professionnelle

Bac+6 et plus