Study Engineer (F/M)

Institut Curie - Research Center; France; On-site; EUR 29,000 - 33,000; Full time

Benefits offered by this job

Institute cafeteria

Remboursement des frais de transport 7

Assurance maladie complémentaire

Job summary

Institut Curie - Research Center en France recrute un(une) Master 1 (R1) pour un contrat temporaire à temps plein dans l’équipe des mécanismes de répression par Polycomb. Vous travaillerez sur des écrans CRISPR et le modelage de cellules souches, avec des analyses transcriptomiques et épigénomiques.

Le candidat idéal possède un Master en sciences de la vie, une expérience en biologie moléculaire et en culture cellulaire, et des notions sur CRISPR et RNA-seq à cellule unique.

Qualifications

• Master’s degree en sciences de la vie ou équivalent.
• Expertise en biologie moléculaire ( clonage, PCR, purification de l’ARN, purification de protéines).
• Expertise en culture cellulaire.
• Connaissance des méthodes CRISPR et/ou RNA-seq à cellule unique.

Responsibilities

• Réaliser des criblages CRISPR basés sur des transcriptomes à cellule unique.
• Mettre au point des modèles cellulaires (iPS/ES) par édition du génome et caractériser leurs propriétés transcriptomiques et épigénomiques.
• Mener des études biochimiques sur des protéines associées à Polycomb.
• Participer aux tâches courantes (maintenance des équipements, renouvellement des stocks, formation des étudiants).

Skills

Molecular biology

Cell culture

CRISPR-based methods

Single-cell RNA-seq

Education

Master’s degree in life sciences

Tools

RNA purification

Protein purification

PCR

Library preparation

Job description

Organisation/Company Institut Curie - Research Center Department Administration Research Field Medical sciences » Cancer research Researcher Profile First Stage Researcher (R1) Positions Master Positions Application Deadline 1 Dec 2026 - 00:00 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Offer Starting Date 21 Oct 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The host institution

The Institut Curie Research Center

France’s leading cancer research and treatment center, Institut Curie unites a renowned research center and a specialist hospital, fostering close collaboration between scientists, clinicians and healthcare professionals. It offers an environment of excellence where expertise comes together around shared values: care, humanity, openness, collaboration, efficiency, innovation, solidarity and commitment.

Team “Mechanisms of Repression by Polycomb Group Proteins”

Our research teamaims to understand the principles that govern gene regulation by the highly conserved family of chromatin modifiers known as Polycomb proteins, from the biochemical to the cellular and organismal levels. We are affiliated with the Institut Curie Research Center’s Genetics and Developmental Biology Unit (Inserm U934/CNRS UMR3215).

• Perform CRISPR-based genetic screens coupled to single cell transcriptomics.
• Engineer various stem cell models (iPS, ES) by genome editing and characterize their transcriptomic and epigenomic properties.
• Conduct biochemical studies of novel Polycomb-associated proteins.
• Participate in all common tasks such as equipment maintenance, renewing stocks, student training, etc.

Activities

• Cloning
• Library preparation (RNA-seq, CUT&RUN-seq, etc.)
• Protein expression and purification, protein pulldowns, Western blot
• Maintenance and differentiation of various stem/progenitor cells
• Lentiviral transduction, transfection
• FACS sorting
• Proliferation and differentiation assays
• Interpretation, synthesis and reporting of results

Constraints and risks

• Biosafety level 2 laboratory
• Routine chemical risks

Candidate Profile

Training and experience required

• Master’s degree in life sciences or equivalent
• Expertise in molecular biology (cloning, PCR, RNA purification, protein purification)
• Expertise in cell culture
• Knowledge of or experience in CRISPR-based methods and/or single-cell RNA-seq

Skills required

• Rigor and scientific integrity
• Ability to work independently
• Perseverance and team spirit

Contract information

Type of contract: Fixed-term contract

Starting date: December 2026-January 2027

Working time: Full time (218 days/year)

Annual Gross Salary: from 29240 € to 33013 € according to the current grids

Benefits: Institute cafeteria,reimbursement of transportation fees up to 70%, supplementary health insurance

Faithful to the legacy of its founder, the Institut Curie is deeply committed to promoting equal opportunities, diversity, and inclusion. Convinced that diversity of backgrounds and experiences contributes to collective performance, we strive to provide everyone with a respectful and equitable working environment and encourage all candidates to apply for our job opportunities.

All our opportunities are open to people with disabilities