POST Doc Position cryoEM/Biochemistry

Instruct-ERIC; Marseille; Sur place; EUR 42 000 - 52 000; Plein temps

Résumé du poste

Instruct-ERIC's CHIKO project seeks a motivated Postdoctoral Researcher to advance structural and functional analysis of viral replication complexes in Chikungunya virus infection. Based in Marseille at AFMB, you will lead Cryo-EM studies and collaborate with international labs over a two-year contract.

The role offers opportunities to publish in top-tier journals, develop expertise in cutting-edge techniques, and contribute to high-impact virology research within a multidisciplinary team.

Qualifications

• PhD in Structural Biology, Virology, Biochemistry, or a related field.
• Experience in macromolecular structure determination (Cryo-Electron Microscopy).
• Strong background in protein biochemistry and molecular biology.
• Familiarity with viral systems (RNA viruses).

Responsabilités

• Characterize replication complexes across infection stages.
• Determine high-resolution structures of replication complexes by Cryo-EM.
• Assess biochemical and enzymatic activities of replication complexes.
• Collaborate with team and report results at meetings and in publications.

Connaissances

Problem-solving

Independent work

Team collaboration

Communication skills

Formation

PhD in Structural Biology, Virology, Biochemistry, or related field

Outils

Cryo-EM

Molecular biology

Description du poste

Jobs in Structural Biology and Related Fields

Postdoctoral Researcher – CHIKO ERC AdG

Position Overview

Position Title: Postdoctoral Researcher in Structural and Functional Virology

Project: CHIKO: Decoding the spatial and temporal sequence of Chikungunya virus infection (ERC Advanced Grant 2025)

Goal: Decode the structural and functional transitions of viral replication complexes during infection.

Supervisor: Juan Reguera (PI), AFMB, INSERM, CNRS/AMU, Marseille, France

Location: AFMB (Architecture et Fonction des Macromolécules Biologiques), Marseille, France

Contract Duration: 2 years (with possibility of extension)

Start Date: January 2027

They are seeking a highly motivated Postdoctoral Researcher to join the CHIKO project. The successful candidate will lead the structural and functional characterization of viral replication complexes at different stages of infection. This role offers the opportunity to contribute to groundbreaking research in viral replication, while gaining expertise in high-impact techniques, publishing in top-tier journals, and collaborating with international labs.

Key Responsibilities

• Characterization of Viral Replication Complexes
  • Investigate the formation, evolution, and function of replication complexes during the viral life cycle.
  • Study the interactions between viral and host proteins with viral RNA and their role in replication.
• Structural Analysis
  • Determine the high-resolution structures of replication complexes in various functional states using Cryo-Electron Microscopy.
  • Analyze structural data to elucidate mechanisms of viral replication and transcription.
• Functional Studies
  • Assess the biochemical and enzymatic activities of replication complexes.
  • Explore the molecular determinants of viral RNA synthesis and processing.
• Collaboration and Reporting
  • Work closely with team members and collaborators to integrate structural and functional findings.
  • Present results at project meetings, conferences, and in peer-reviewed publications.

Required Qualifications

Education

• PhD in Structural Biology, Virology, Biochemistry, or a related field.

Technical Skills

• Experience in macromolecular structure determination (e.g., Cryo-Electron Microscopy or related techniques).
• Strong background in protein biochemistry and molecular biology.
• Familiarity with viral systems (preferably RNA viruses).

Soft Skills

• Excellent problem-solving and analytical skills.
• Ability to work independently and collaboratively in a multidisciplinary team.
• Strong communication skills .

Work Environment

• Cutting-edge facilities: First-hand access to PBSIM (Marseille), Cryo-EM at Madrid CNB, and CRCM proteomics facility for comprehensive structural and interactomics analyses.
• Collaborative network: Opportunity to work with leading experts in virology, structural biology, and interactomics.
• Training opportunities: Participation in workshops, conferences, and advanced training to further develop expertise.