DNA Origami & Protein Engineering Intern

Inserm France; Rennes; Hybrid; EUR 11,000 - 16,000; Full time

Job summary

Inserm France is offering an internship in Molecular Biology focused on DNA origami to control kinase assemblies. You will express and purify proteins, assemble DNA nanostructures, and bioconjugate proteins on DNA origami, followed by AFM validation and enzymatic activity assays.

This project supports a PhD focusing on IRE1 activation mechanisms in cellular stress response. The position is a 6-month full-time internship, suitable for Master 1–2 students with a strong background in chemical

Qualifications

• Student enrolled in Master 1–2 in chemical biology, biochemistry, biophysics or molecular biology.
• Strong background in protein expression and biochemical assays.
• Interest in DNA nanostructures and protein–DNA conjugates.

Responsibilities

• Express, purify and functionalize the protein kinase N-terminus.
• Assemble and purify DNA origami structures.
• Bioconjugate proteins on the DNA origami using DNA hybridization.
• Validate functionalized Protein-DNA nanostructures by AFM.
• Evaluate enzymatic activities using established biochemical assays.

Skills

Molecular biology

Protein expression

Bioconjugation

Enzymatic assays

Education

Master's degree in life sciences

Tools

AFM microscopy

CryoEM

DNA origami

Job description

Inserm France is offering an internship in Molecular Biology focused on DNA origami to control kinase assemblies. You will express and purify proteins, assemble DNA nanostructures, and bioconjugate proteins on DNA origami, followed by AFM validation and enzymatic activity assays.

This project supports a PhD focusing on IRE1 activation mechanisms in cellular stress response. The position is a 6-month full-time internship, suitable for Master 1–2 students with a strong background in chemical