Research Engineer Process Development (F/M)

Euraxess; Saint-Cloud; Hybrid; EUR 55,000 - 75,000; Full time

Benefits offered by this job

Company cafeteria

70% coverage of annual public transit

Company health insurance

Job summary

Institut Curie is seeking a researcher for the CellAction Process Development group at Saint-Cloud to develop and optimize manufacturing processes for cell- and gene-based therapies. You will transfer pre-GMP workflows, design analytical methods, and ensure product quality in a GMP-regulated setting.

The role requires 2-5 years in cell/gene therapy process development, proficiency in aseptic mammalian culture, and strong communication to collaborate across teams.

Qualifications

• Master's degree or PhD in Biotechnology, Biochemical Engineering, or related field.
• 2-5 years of experience in process development (cell therapy, gene therapy, or drug development).
• Fluency in English; French is a plus.

Responsibilities

• Develop and optimize manufacturing processes for cell and gene therapies, including viral/non-viral vectors and genome editing.
• Transfer pre-GMP processes into robust, reproducible workflows suitable for clinical manufacturing.
• Develop analytical methods and monitor CPPs and CQAs to ensure product quality.
• Collaborate with multidisciplinary teams, contribute to troubleshooting, and support continuous process improvement.
• Prepare technical documentation and ensure GMP regulatory compliance.

Skills

Cell culture

Gene therapy

Aseptic technique

Analytical skills

Teamwork

Education

Master's degree or PhD in Biotechnology/related field

Tools

CRISPR-Cas

Flow cytometry

Viral vectors

Job description

Organisation/Company Institut Curie - Research Center Department Administration Research Field Medical sciences Cancer research Researcher Profile Recognised Researcher (R2) Positions PhD Positions Application Deadline 25 Nov 2026 - 00:00 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Offer Starting Date 25 Sep 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Host Institution

The Curie Institute Research Center

The "Institut Curie" is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international representativeness.

The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Laboratory - CellAction

CellAction is part of Institut Curie's commitment to building unique expertise in cell and gene therapy. It integrates multidisciplinary competencies in bioinformatics, target discovery and validation, molecular biology, genome editing, viral and non-viral vector design, cell engineering, and the development of in vitro and in vivo tumor models for cell and gene therapy applications. Furthermore, CellAction provides pre-GMP process development expertise, aiming to generate fully characterized, GMP-ready cell therapy products that can be manufactured in dedicated GMP facilities and subsequently evaluated in clinical settings.

In 2025, CellAction was permanently established at the Saint-Cloud site of Institut Curie.

At the Process Development group at CellAction, our activities focus on the development and optimization of manufacturing processes for cell- and gene-based therapies, ensuring translational feasibility and compliance with regulatory standards for clinical-grade production.

• Develop and optimize manufacturing processes for cell and gene therapies, including viral/non-viral vectors and genome editing.
• Transfer pre-GMP processes into robust, reproducible workflows suitable for clinical manufacturing.
• Develop analytical methods and monitor critical process parameters (CPPs) and critical quality attributes (CQAs) to ensure product quality.
• Collaborate with multidisciplinary teams, contribute to troubleshooting, and support continuous process improvement.
• Prepare technical documentation and ensure compliance with GMP and regulatory requirements.

Identify innovative approaches to improve process efficiency and maintain technology watch in the field of cell and gene therapy.

What We Offer

• Opportunity to work on cutting-edge therapies
• Dynamic and collaborative environment
• Competitive salary and benefits package

Profile and Qualification

Basic Qualifications

• Master's degree or PhD in Biotechnology, Biochemical Engineering, or related field

2-5 years of experience in process development (cell therapy, gene therapy, or drug development)

Preferred Qualifications

• Demonstrated proficiency in aseptic mammalian cell culture, with preference for experience in primary T-cell culture, cell activation, and cell expansion systems (flasks, bags, or bioreactors), viral transduction techniques, immunophenotyping (e.g. Flow cytometry)
• Knowledge of analytical characterization and critical quality attributes (CQAs), preferably for cell and gene therapy drug products, including titer, purity, potency, and sterility.
• Hands-on experience with site-specific gene-editing technologies (e.g. CRISPR-Cas) is desirable; however, it is not mandatory.
• Excellent written and verbal communication skills, with the ability to clearly present technical and scientific information to multidisciplinary teams.
• Knowledge of GMP environment and regulatory expectations
• Strong analytical and problem-solving skills
• Ability to work in a multidisciplinary and fast-paced environment

Fluent in English; French is a plus

Required Skills and Competencies

• Ability to work independently in managing routine tasks
• Strong organizational skills
• Adaptability and responsiveness
• Ability to work effectively as part of a team

All our opportunities are open to individuals with disabilities.

Contract Information

Start date: As soon as possible

Contract duration: 12 months, renewable for an additional 12 months

Working time: Full-time - 39 hours per week

Salary:According to current salary scales

Benefits: Company cafeteria, 70% coverage of annual public transportation pass, company health insurance

Faithful to the legacy of its founder, the Institut Curie is deeply committed to promoting equal opportunities, diversity, and inclusion. Convinced that diversity of backgrounds and experiences contributes to collective performance, we strive to provide everyone with a respectful and equitable working environment and encourage all candidates to apply for our job opportunities.