Chercheur postdoctorant (M/F)

EURAXESS Ireland; Paris; Hybride; EUR 42 000 - 54 000; Plein temps

Résumé du poste

CNRS – Institut de Biologie Paris-Seine (IBPS) in Paris invites applications for a postdoctoral researcher to explore molecular mechanisms of olfactory orifice formation in zebrafish. The project targets skin cell remodelling above the olfactory placode and signals between placodal cells and skin epithelium.

The role integrates developmental biology, molecular biology, single-cell genomics and live imaging, with collaboration across sectors and potential publications.

Qualifications

• PhD in developmental biology, cell biology, molecular biology, genetics or a related field.
• Strong experience in transcriptomics and bioinformatic analysis, preferably single-cell RNA sequencing.
• Interest in developmental biology, epithelial remodelling and tissue morphogenesis.
• Experience with zebrafish, FACS, molecular biology, genetics, imaging or quantitative image analysis would be an advantage, but is not required.

Responsabilités

• Characterise the molecular profiles of remodelled skin cells and compare them with neighbouring skin cells using FACS and single-cell transcriptomics (Smart-seq3).
• Identify and validate candidate molecular regulators of epithelial remodelling and skin–placode interactions using molecular, imaging and genetic approaches.
• Characterise placodal cell populations and investigate their potential molecular signals involved in communication with the skin epithelium.
• Analyse the consequences of candidate gene perturbations using zebrafish genetics, live imaging and quantitative image analysis.
• Integrate molecular, transcriptomic and imaging data and contribute to publications and scientific presentations.

Connaissances

Transcriptomics

Bioinformatics

Single-cell RNA-seq

Developmental biology

Epithelial remodelling

Zebrafish

FACS

Imaging

Formation

PhD in life sciences

Description du poste

Organisation/Company CNRS Department Développement, Adaptation, Vieillissement Research Field Mathematics History » History of science Researcher Profile Recognised Researcher (R2) Application Deadline 2 Oct 2026 - 23:59 (UTC) Country France Type of Contrat Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 4 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The postdoctoral researcher will investigate the molecular mechanisms underlying olfactory orifice formation in zebrafish, focusing on the interactions between the olfactory placode and the overlying skin epithelium.
A major objective will be to identify the molecular identity and function of specialised skin cells that become remodelled above the olfactory placode, and to determine how they acquire the properties required for orifice formation. The project will also investigate the contribution of placodal cells, including non-neuronal mantle cells, to skin remodelling and orifice opening.
The project combines developmental and molecular biology, single-cell transcriptomics, bioinformatics, zebrafish genetics and live imaging.

The postdoctoral researcher will:

• characterise the molecular profiles of remodelled skin cells and compare them with neighbouring skin cells using FACS and single-cell transcriptomics (Smart-seq3), in collaboration with the Inforbio platform;
• identify and validate candidate molecular regulators of epithelial remodelling and skin–placode interactions using molecular, imaging and genetic approaches;
• characterise placodal cell populations and investigate their potential molecular signals involved in communication with the skin epithelium;
• analyse the consequences of candidate gene perturbations using zebrafish genetics, live imaging and quantitative image analysis;
• integrate molecular, transcriptomic and imaging data and contribute to publications and scientific presentations.

The position is based at the Institut de Biologie Paris-Seine (IBPS), Sorbonne University / CNRS / INSERM, within the Development, Adaptation and Ageing unit (Dev2A; CNRS UMR8263 / INSERM U1345).
The researcher will join the research project led by Marion Baraban, project coordinator of the ANR OPEN project, within Marie Breau's team. The project brings together expertise in developmental biology, zebrafish genetics, molecular biology, single-cell genomics, quantitative imaging and mechanobiology.
The researcher will work closely with the Inforbio bioinformatics platform, as well as with technical and engineering support for zebrafish genetics and imaging. The project also involves collaborations with Institut Curie and biophysicists at IBPS.
The position is funded by the ANR OPEN project for 12 months, with the possibility of a one-year extension, and offers a highly collaborative environment with substantial scientific independence.

• PhD in developmental biology, cell biology, molecular biology, genetics or a related field;
• Strong experience in transcriptomics and bioinformatic analysis, preferably single-cell RNA sequencing;
• Interest in developmental biology, epithelial remodelling and tissue morphogenesis;
• Experience with zebrafish, FACS, molecular biology, genetics, imaging or quantitative image analysis would be an advantage, but is not required.