Biochemistry Lead for High-Sensitivity Diagnostics

Proteins.1; Espoo; Hybrid; EUR 95,000 - 125,000; Full time

Job summary

Proteins.1 is building a PCR for a novel diagnostic platform and seeks a hands-on scientist to translate assay concepts into robust, transferable workflows. You will own surface functionalization, produce standard control proteins, and direct a biochemist team as the platform moves toward a commercial device.

The role focuses on establishing reproducible chemistry, with experience in single-molecule counting workflows and high-sensitivity immunoassays. Espoo-based with hybrid work support.

Qualifications

• Hands-on mastery of protein synthesis and recombinant expression/purification, including QC and stability work.
• Proven experience in surface chemistry for site-specific biomolecule immobilization and non-specific binding suppression.
• Track record developing and validating high-sensitivity immunoassays or single-molecule counting workflows to strict specs.
• Ability to structure rigorous DOE, write SOPs and a legible ELN.
• Deep expertise in binder kinetics (SPR/BLI) and fluorophore conjugation; experience with liquid handling automation.

Responsibilities

• Build the workflows: turn assay concepts into robust, transferable protocols and SOPs, written and ELN-friendly.
• Own the surfaces: establish and characterize functionalization chemistry on glass, silicon and plastic for site-specific immobilization.
• Make the reagents: produce standard control proteins with QC and stability data.
• Validate: develop high-sensitivity immunoassay and single-molecule workflows to strict LoB/LoD/LoQ specs.
• Direct the work: design and review experiments of biochemist team, guiding execution.
• Build the lab: specify instruments, qualify vendors, own results end-to-end at pre-seed stage.

Skills

Protein synthesis

Recombinant expression/purification

Surface chemistry

Single-molecule assays

DOE design

SOPs & ELN

Binder kinetics (SPR/BLI)

Fluorophore conjugation

Lab automation experience

Data analysis for high-count readouts

Education

MSc/PhD in relevant field

Tools

Cell-free protein synthesis

SDS-PAGE

SEC

XPS/ToF-SIMS

Liquid handling automation

Bead-based assays

Job description

Proteins.1 is building a PCR for a novel diagnostic platform and seeks a hands-on scientist to translate assay concepts into robust, transferable workflows. You will own surface functionalization, produce standard control proteins, and direct a biochemist team as the platform moves toward a commercial device.

The role focuses on establishing reproducible chemistry, with experience in single-molecule counting workflows and high-sensitivity immunoassays. Espoo-based with hybrid work support.