Research Assistant (Doctoral Researcher/PhD)

Philipps-Universität Marburg; Marburg; On-site; EUR 33,000 - 42,000; Part time

Benefits offered by this job

Landesticket for public transport in H

TRR 440 graduate school membership

Support from MARA/International Office

Job summary

Philipps-Universität Marburg seeks a motivated researcher to conduct cutting-edge RNA biochemistry in an interdisciplinary setting. The position is 65% of full-time and funded for a doctoral project within a public-service framework (TV-H E 13). It offers collaboration with TRR 440 and a strong graduate environment.

The role emphasizes RNA biochemistry, mitochondrial biology, and development of small molecule ligands, with opportunities for independent research and doctoral completion.

Qualifications

• MSc degree or equivalent in biochemistry or related field.
• Practical experience in biochemistry or molecular biology.
• Excellent English proficiency; German language knowledge is a plus.

Responsibilities

• Scientific services in research and teaching, focusing on RNA-ligand interactions.
• Identify and characterize new 7S RNA-binding proteins.
• Develop small molecule libraries and HT screening platforms.
• Work on 7S RNA-targeting ligands using SHAPE-MaP.
• Express and purify recombinant mitochondrial proteins.
• Prepare mitochondrial extracts.
• Synthesize and purify DNA and RNA for biochemical experiments.

Skills

MSc in Biochemistry

Molecular biology experience

English proficiency

German language knowledge

Team oriented

Education

MSc in Biochemistry

Job description

This position is offered for a period of 3 years, if no former times of qualification must be considered. The starting date is as soon as possible. The position is part-time (65% of regular working hours) with salary and benefits commensurate with a public service position in the state Hesse, Germany (TV-H E 13, 65%).

We seek a motivated and dedicated individual to conduct cutting-edge RNA research in an interdisciplinary and highly collaborative environment. This position is funded as part of the CRC/Transregio 440: "smART - specific mRNA targeting", with the goal of developing new RNA-based technologies to control the function of disease-relevant eukaryotic mRNAs. In this project, we aim to establish the biological function of 7S RNA, a non-coding, mitochondrial DNA-encoded transcript. We will approach this primarily with biochemical methods involving purified recombinant proteins and RNA, and by developing precision small molecule ligands to modulate the function of 7S RNA in living cells.

Tasks:

• Scientific services in research and teaching, with a focus on RNA-ligand interactions
• Identification and characterization of new 7S RNA-binding proteins
• Development of small molecule libraries and high-throughput screening platforms to characterize
• 7S RNA-targeting ligands using structural probing techniques (e.g., SHAPE-MaP)
• Expression and purification of recombinant mitochondrial proteins
• Preparation of mitochondrial extracts
• Synthesis and purification of DNA and RNA molecules for biochemical experiments

The position is limited to a time period deemed adequate for the completion of a doctoral degree. As part of the assigned duties, there will be ample opportunity to conduct the independent scientific research necessary for the completion of a doctorate. The limitation complies to Section 2(1) of the German Academic Fixed-Term Contract Act (WissZeitVG).

Profile:

• MSc degree or equivalent in biochemistry, biolgy or a related field in the life and natural sciences
• Highly motivated individual who thrives in working as part of a team
• Practical experience in the field of biochemistry and/or molecular biology is required
• Critical thinking and an enthusiasm for scientific inquiry and experimental work
• Prior experience in nucleic acid biochemistry, mitochondrial RNA biology & transcription is an advantage
• Excellent English proficiency is required; knowledge of German is an advantage

Disposition to own scientific qualification i.e., a doctorate project in the area of RNA biochemistry is expected.

We offer:

• A strong research environment within an interdisciplinary team comprising over 20 research groups in the field of RNA biochemistry and RNA therapeutics
• Membership in the integrated graduate school of TRR 440, which offers workshops and seminars on RNA research, bioinformatics, career development, and science communication
• The "Landesticket" for free use of public transportation in Hesse

We actively support the professional development of junior researchers by the offers of the IRTG of the TRR 440, the Marburg Research Academy (MARA), the International Office and the Higher Education Didactics Office.

Contact for more Information

Dr. Benedict Tan

[phone]

[e-mail]

We support women and strongly encourage them to apply. In areas where women are underrepresented, female applicants will be preferred in case of equal qualifications. As a certified family-friendly university, we support our employees in balancing family and career. A reduction of working time is possible. Applicants with a disability as discribed in the Social Security Code (Section 2(2) and (3) of Book IX of the Social Security Code (SGB IX)) will be preferred in case of equal qualifications. Application and interview costs can not be refunded.