Research Associate - Mitochondrial Therapy Translational (100%)

Witzig The Office Company AG; Basel; Vor Ort; CHF 80.000 - 100.000; Vollzeit

Zusammenfassung

Witzig The Office Company AG is seeking an experienced Research Associate to join the Mitochondrial Biology and Therapy Group led by Dr. Temurkhan Ayupov. The group focuses on understanding mitochondrial dysfunction and its contribution to neurodegeneration, developing therapies for vision loss.

This role involves designing and analyzing CRISPR screens to identify novel therapeutic targets and will require expertise in molecular biology. Candidates should be highly motivated to contribute to an innovative research environment.

Qualifikationen

• Experience in CRISPR technology and genome-wide screening.
• Strong analytical skills to design and evaluate experiments.
• Background in molecular biology, neuroscience, or related fields.

Aufgaben

• Design and execute CRISPR screens to identify therapeutic targets.
• Analyze data to understand mitochondrial function in neurodegeneration.
• Collaborate with the research team to publish findings.

Jobbeschreibung

The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking an experienced and highly motivated Research Associate to join the Mitochondrial Biology and Therapy Group led by Dr. Temurkhan Ayupov.

IOB combines basic and clinical research to advance the understanding of vision and its diseases and to develop new therapies for vision loss. We offer an environment where your expertise will be valued, your abilities challenged, and your scientific knowledge expanded.

The Mitochondrial Biology and Therapy Group investigates how mitochondrial dysfunction contributes to neurodegeneration and develops therapeutic strategies for these diseases. A major focus is the development of cell-type-targeted mitochondrial transfer therapies. To accelerate this work, we are establishing genome-wide CRISPR screening as a discovery platform to identify genes and pathways that govern donor mitochondria internalization and integration. In this role you will design, execute, and analyze pooled CRISPR knockout, activation, and interference screens to uncover novel therapeutic targets and contribute to the group's translational programs.