Coupling Scientist (f/m/x)

MADx – Macro Array Diagnostics GmbH; Wien; On-site; EUR 42,000 - 52,000; Full time

Benefits offered by this job

Public transport pass

Pluxee vouchers

Ownership from day one

Collaborative culture

Sustainability & inclusion

Job summary

MADx – Macro Array Diagnostics GmbH in Vienna seeks a Coupling Scientist to optimize protein coupling/conjugation methods for allergen and protein immobilization on microspheres used in immunoassays. You will improve efficiency, reproducibility, and stability while preparing processes for transfer to Engineering and Production.

Responsibilities include protocol standardization, documentation under GDP, and collaboration with cross-functional teams to ensure scalable, high-quality processes.

Qualifications

• BSc or MSc in chemistry, or equivalent.
• Experience with protein conjugation and immobilization.
• Good understanding of protein properties and coupling efficiency.
• Experience developing, optimizing, and troubleshooting lab methods and processes.
• Strong analytical and problem-solving skills with data-driven approach.
• GDP knowledge and accurate documentation practices.

Responsibilities

• Develop, evaluate, and optimize protein coupling and conjugation methods for immobilization of allergens, antibodies, and other proteins onto microspheres for immunoassay applications.
• Improve existing coupling methods for efficiency, reproducibility, stability, and overall assay performance.
• Troubleshoot coupling-related issues, identify root causes, and implement corrective actions and process improvements.
• Develop and standardize coupling protocols to ensure reliable results across proteins, batches, and production conditions.
• Prepare coupling methods and processes for transfer to Engineering and Production, including characterization and documentation.
• Collaborate with Engineering and Production to support method transfer, scale-up, and implementation of improved procedures.
• Document R&D activities and results in compliance with GDP and quality requirements; initiate changes as needed.
• Prepare and maintain department QM documentation, including coupling protocols, SOPs, and workflows.
• Initiate changes to methods and documentation to support continuous improvement and quality compliance.

Skills

Protein chemistry

Conjugation techniques

Process optimization

Troubleshooting

Documentation & GDP

Interdisciplinary collaboration

Data-driven decisions

English communication

Education

BSc or MSc in chemistry

Job description

We have revolutionized allergy diagnostics and have been operating successfully in 115 countries and counting for over 10 years with our diagnostic products and patented technologies. Our products help clarifying allergies in a single step – for humans and animals alike. Allergies are diagnosed in a highly specific manner so that patients receive help by their specialist in no time. We increase quality of life, enable personalized treatment, advance research and relieve our health system.

For our Conjugation team, we are looking for an Coupling Scientist who will optimise our coupling methods.

What We Offer

• A full-time position with real ownership from day one
• An annual pass for Vienna's public transport, plus Pluxee vouchers
• A team that cares as much about veterinary patients as human ones
• A culture where questions, ideas, and pushback are genuinely welcome
• A workplace shaped by sustainability, equity, diversity, inclusion, and mutual respect

What You'll Do

• Develop, evaluate, and optimize protein coupling and conjugation methods for the immobilization of allergens, antibodies, and other proteins onto microspheres (e.g. polymer or nanobeads) for immunoassay applications.
• Continuously improve existing coupling methods and processes with a focus on efficiency, reproducibility, stability, robustness, and overall assay performance and evaluate and optimize existing protein couplings to enhance product quality, consistency, and long-term stability.
• Troubleshoot coupling-related issues, identify root causes of performance variability, and proactively implement corrective actions and process improvements.
• Develop and standardize coupling protocols, ensuring reliable and reproducible results across different proteins, batches, and production conditions.
• Prepare coupling methods and processes for transfer to Engineering and Production, including process characterization, identification of critical process parameters, optimization of workflows, and preparation of technical documentation.
• Collaborate closely with Engineering and Production teams to support successful method transfer, process scale-up, and implementation of new or improved coupling procedures.
• Document all R&D activities, experimental results, and process improvements in compliance with Good Documentation Practices (GDP) and applicable quality management requirements and initiate and implement changes to existing methods, protocols, and documentation to support continuous improvement and compliance with quality requirements.
• Prepare, review, and maintain department-specific quality management (QM) documentation, including coupling protocols, SOPs, and technical workflows.
• Initiate and implement changes to existing methods, protocols, and documentation to support continuous improvement and compliance with quality requirements.

What You Bring

• BSc or MSc in chemistry
• Hands-on experience in protein chemistry, protein conjugation, immobilization techniques, or surface functionalization as well as process optimization, scale-up, or method transfer to production is an advantage
• Good understanding of protein properties, chemical reactions and factors influencing coupling efficiency, stability and reproducibility
• Experience in the development, optimization, and troubleshotting of laboratory methods and processes
• Strong analytical and problem-solving skills, with a structured and data-driven approach to identify root causes and implementing improvements
• Accurate and reliable documentation skills, with an understanding of Good Documentation Practices (GDP).
• Independent, proactive, and solution-oriented working style, with a strong focus on continuous improvement.
• Good communication skills and the ability to collaborate effectively with interdisciplinary teams, including R&D, Engineering, and Production
• Very good English skills; German skills are an advantage

Compensation

For this position, we offer a market-competitive minimum annual gross salary of EUR 47.220 based on full-time employment, which is above the applicable collective agreement minimum salary. Final compensation will be determined based on qualifications and experience.