Senior Bioprocess Downstream Engineer — Purification

Placements24; Gqeberha; Hybrid; ZAR 1,200,000 - 1,800,000; Full time

Benefits offered by this job

Health coverage

Performance bonuses

Stock options

Professional development opportunities

Conference attendance

Job summary

Placements24, on behalf of a biotechnology firm in Port Elizabeth, seeks a Senior Chemical Engineer specializing in downstream processing to design, optimize, and scale purification for biologics. You will lead chromatography, filtration, and viral inactivation steps, scale from lab to pilot and production, and implement GMP-compliant methods while collaborating with R&D, analytics and manufacturing.

Candidates hold an MSc/PhD in Chemical or Biochemical Engineering with 6+ years of downstream

Qualifications

• MSc/PhD in Chemical or Biochemical Engineering.
• 6+ years in biopharmaceutical downstream processing.
• Expertise in chromatography and filtration techniques.
• Experience with GMP validation principles.
• Strong analytical and problem-solving skills.

Responsibilities

• Design, develop and optimize downstream processing trains for biologics, including chromatography, filtration and viral inactivation steps.
• Scale-up purification processes from lab to pilot and commercial manufacturing.
• Develop and validate purification methods per GMP guidelines.
• Troubleshoot downstream processing equipment and operations.
• Perform process modeling and simulation to identify improvements.
• Collaborate with cross-functional teams for technology transfer and implementation.
• Stay updated on industry trends in downstream processing.
• Contribute to continuous improvement to reduce costs.

Skills

Biopharmaceutical downstream

Chromatography

Process modeling

Education

MSc/PhD in Chemical Engineering or Biochemical Engineering

Tools

Process simulation software

Job description

Placements24, on behalf of a biotechnology firm in Port Elizabeth, seeks a Senior Chemical Engineer specializing in downstream processing to design, optimize, and scale purification for biologics. You will lead chromatography, filtration, and viral inactivation steps, scale from lab to pilot and production, and implement GMP-compliant methods while collaborating with R&D, analytics and manufacturing.

Candidates hold an MSc/PhD in Chemical or Biochemical Engineering with 6+ years of downstream