Chemical Process Development Engineer - Pharmaceuticals

Placements24; Bloemfontein; Híbrido; ZAR 900 000 - 1 200 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Health insurance

Retirement plan

Paid time off

Professional development

Relocation assistance

Resumo da oferta

Placements24 is seeking an innovative Chemical Process Development Engineer to join the R&D team in Welkom, Free State. You will drive the development and optimization of API synthesis routes, oversee bench-scale experiments, and lead pilot plant trials for scale-up and tech transfer to production.

The role requires strong organic chemistry, reaction engineering, and GMP-aware mindset. You'll collaborate with analytical and manufacturing teams, stay current with literature, and help evaluate new

Qualificações

• Master's degree or Ph.D. in Chemical Engineering or Organic Chemistry.
• 3–5 years of experience in chemical process development, preferably within pharma or fine chemicals.
• Strong understanding of organic synthesis, reaction kinetics, thermodynamics, and separation techniques.
• Hands-on experience with laboratory equipment and pilot plant operations.
• Familiarity with GMP regulations and validation principles.
• Proficiency in using process simulation software is an advantage.

Responsabilidades

• Design and execute laboratory experiments to develop and optimize chemical synthesis routes for APIs.
• Conduct process characterization studies to understand critical process parameters and ensure robustness.
• Perform scale-up calculations and lead pilot plant runs to validate process viability and gather data for commercialization.
• Develop comprehensive process documentation, including batch records, development reports, and technology transfer packages.
• Collaborate closely with analytical chemists, formulation scientists, and manufacturing personnel.
• Identify and troubleshoot process-related issues during development and initial manufacturing phases.
• Ensure all development activities comply with GMP and regulatory guidelines.
• Evaluate and implement new technologies to improve process efficiency, safety, and environmental performance.
• Stay updated on literature and industry trends relevant to pharmaceutical process development.
• Contribute to intellectual property generation through patent filings and internal innovation disclosures.

Conhecimentos

Organic chemistry

Reaction engineering

Process scale-up

Bench-scale experiments

Pilot plant operations

GMP compliance

Data analysis

Formação académica

Master's degree in Chemical Engineering

Ph.D. in Chemical Engineering or Organic Chemistry

Ferramentas

Aspen Plus

CHEMCAD

Descrição da oferta de emprego

About the Role

Our client, a rapidly growing pharmaceutical company, is seeking an innovative Chemical Process Development Engineer to join their research and development team in Welkom, Free State. This role is crucial for the development and optimization of chemical processes used in the manufacturing of active pharmaceutical ingredients (APIs). The ideal candidate will have a strong foundation in organic chemistry, reaction engineering, and process scale-up, with a specific focus on pharmaceutical applications. You will be involved in bench-scale experimentation, pilot plant trials, and technology transfer to manufacturing. This position offers an exciting opportunity to contribute to the development of life-saving medicines within the Welkom facility.

Key Responsibilities

• Design and execute laboratory experiments to develop and optimize chemical synthesis routes for APIs.


• Conduct process characterization studies to understand critical process parameters and ensure robustness.


• Perform scale-up calculations and lead pilot plant runs to validate process viability and gather data for commercialization.


• Develop comprehensive process documentation, including batch records, development reports, and technology transfer packages.


• Collaborate closely with analytical chemists, formulation scientists, and manufacturing personnel.


• Identify and troubleshoot process-related issues during development and initial manufacturing phases.


• Ensure all development activities comply with Good Manufacturing Practices (GMP) and relevant regulatory guidelines.


• Evaluate and implement new technologies to improve process efficiency, safety, and environmental performance.


• Stay updated on scientific literature and industry trends relevant to pharmaceutical process development.


• Contribute to intellectual property generation through patent filings and internal innovation disclosures.

Requirements

• Master's degree or Ph.D. in Chemical Engineering or Organic Chemistry.


• 3-5 years of experience in chemical process development, preferably within the pharmaceutical or fine chemical industry.


• Strong understanding of organic synthesis, reaction kinetics, thermodynamics, and separation techniques.


• Hands-on experience with laboratory equipment and pilot plant operations.


• Familiarity with GMP regulations and validation principles.


• Proficiency in using process simulation or modeling software is an advantage.


• Excellent written and verbal communication skills, with the ability to document complex processes clearly.


• Strong analytical and problem-solving capabilities.


• Ability to work effectively in a fast-paced, collaborative research environment in Welkom.


• Detail-oriented with a commitment to accuracy and quality.

Benefits

• Competitive annual salary and potential for annual bonuses.


• Comprehensive health, dental, and vision insurance plans.


• Company-sponsored retirement savings plan.


• Generous paid time off, including vacation, sick days, and public holidays.


• Opportunities for professional development, including attendance at scientific conferences.


• Access to cutting-edge pharmaceutical research and development facilities.


• A collaborative and innovative work environment focused on advancing healthcare.


• Potential for career growth within a growing pharmaceutical organization in the Free State.


• Relocation assistance package for candidates moving to Welkom.