Process Development Chemist (Pharmaceutical)

Placements24; Bloemfontein; On-site; ZAR 600,000 - 900,000; Full time

Job summary

Placements24 in Bloemfontein is seeking a Process Development Chemist to optimize and scale up pharmaceutical synthesis for intermediates and APIs. You will apply organic chemistry and process engineering to develop robust, safe, and cost-effective manufacturing methods.

The role involves collaborating with engineering teams for technology transfer from lab to pilot plant, focusing on safety, yield, and efficiency, with ongoing opportunities for professional development in a dynamic

Qualifications

• PhD or Master's degree in Organic Chemistry, Process Chemistry, or Chemical Engineering.
• Minimum of 5 years of experience in process development within the pharmaceutical or fine chemical industry.
• Strong background in synthetic organic chemistry and reaction mechanism.
• Experience with process scale-up, hazard evaluation, and troubleshooting manufacturing issues.
• Proficiency with analytical techniques for chemical characterization.

Responsibilities

• Develop, optimize, and scale-up chemical synthesis routes for pharmaceutical intermediates and APIs.
• Conduct laboratory experiments to investigate reaction kinetics, thermodynamics, and safety parameters.
• Identify and mitigate potential process hazards, ensuring safe operating procedures are developed.
• Collaborate with engineering teams to ensure smooth technology transfer from lab to pilot plant and commercial scale.
• Troubleshoot process issues and implement solutions to improve yield, purity, and efficiency.
• Characterize materials using analytical techniques such as NMR, Mass Spectrometry, and Chromatography.

Skills

Synthetic chemical expertise

Reaction mechanisms

Analytical techniques

Teamwork

Problem solving

Education

PhD or Master's in Organic Chemistry / Process Chemistry / Chemical Engineering

Tools

NMR

Mass Spectrometry

Chromatography

Job description

About the Role

Our client is seeking a talented and innovative Process Development Chemist to join their manufacturing team in Bloemfontein . This role is central to optimizing and scaling up chemical synthesis processes for pharmaceutical intermediates and Active Pharmaceutical Ingredients (APIs). You will apply your expertise in organic chemistry and process engineering to develop robust, safe, and cost-effective manufacturing methods, ensuring efficient production. This is a prime opportunity to contribute to the advancement of pharmaceutical manufacturing in the heart of the Free State, working within a supportive environment that values scientific rigor and continuous improvement.

Key Responsibilities

• Develop, optimize, and scale-up chemical synthesis routes for pharmaceutical intermediates and APIs.
• Conduct laboratory experiments to investigate reaction kinetics, thermodynamics, and safety parameters.
• Identify and mitigate potential process hazards, ensuring safe operating procedures are developed.
• Collaborate with engineering teams to ensure smooth technology transfer from lab to pilot plant and commercial scale.
• Troubleshoot process issues and implement solutions to improve yield, purity, and efficiency.
• Characterize materials using analytical techniques such as NMR, Mass Spectrometry, and Chromatography.

Requirements

• PhD or Master's degree in Organic Chemistry, Process Chemistry, or Chemical Engineering.
• Minimum of 5 years of experience in process development within the pharmaceutical or fine chemical industry.
• Strong background in synthetic organic chemistry and reaction mechanism.
• Experience with process scale-up, hazard evaluation, and troubleshooting manufacturing issues.
• Proficiency with analytical techniques for chemical characterization.
• Excellent problem-solving skills and ability to work effectively in a team.

Benefits

• Competitive salary and performance-based incentives.
• Comprehensive medical aid and retirement fund contributions.
• Opportunities for professional development and specialized training.
• A stimulating work environment focused on innovation and operational excellence.
• Direct impact on the successful production of vital pharmaceutical compounds.