Senior Process Development Chemist

Placements24; Bloemfontein; Presencial; ZAR 900.000 - 1.200.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Annual bonus

Medical aid

Retirement fund

Life insurance

Descripción de la vacante

Placements24 in Bloemfontein is seeking a Senior Process Development Chemist to drive development, optimization, and scale-up of API production processes. The role emphasizes robust, safe, cost-effective processes aligned with regulatory standards and hands-on laboratory work across multiple departments.

The ideal candidate will have 5+ years of pharmaceutical process development experience, with strong expertise in organic synthesis, process chemistry, and engineering principles.

Formación

• MSc or Ph.D. in Organic Chemistry, Process Chemistry, or a related field.
• Minimum of 5 years of experience in pharmaceutical process development.
• Strong knowledge of organic synthesis, reaction mechanisms, and purification techniques.
• Experience with process scale-up, pilot plant operations, and technology transfer.
• Familiarity with Process Analytical Technology (PAT) and Quality by Design (QbD) principles.
• Proficiency in analytical techniques such as HPLC, GC, NMR, and MS.

Responsabilidades

• Develop and optimize synthetic routes for APIs, focusing on scalability, safety, and cost-effectiveness.
• Conduct process hazard analyses and implement appropriate safety measures.
• Perform reaction kinetics studies and thermodynamic analysis to understand process behavior.
• Develop analytical methods for monitoring reaction progress and product quality.
• Scale-up chemical processes from laboratory to pilot plant and commercial manufacturing.
• Troubleshoot process deviations and implement corrective actions.
• Collaborate with engineers, analytical chemists, and regulatory affairs specialists.
• Ensure all activities comply with cGMP and other relevant regulatory requirements.

Conocimientos

Organic synthesis

Process chemistry

Chemical engineering

Educación

MSc or PhD in Organic Chemistry/Process Chemistry

Herramientas

HPLC

GC

NMR

MS

Descripción del empleo

About the Role

Our client, a dynamic pharmaceutical company located in Bloemfontein , is seeking a highly skilled Senior Process Development Chemist to join their innovative Manufacturing and Technology team. This role is critical for the development, optimization, and scale-up of chemical processes for the production of active pharmaceutical ingredients (APIs). You will be responsible for ensuring that processes are robust, safe, cost-effective, and compliant with regulatory standards. The ideal candidate will possess extensive experience in organic synthesis, process chemistry, and chemical engineering principles. This is an excellent opportunity to contribute to the development of life-changing medicines and work within a state-of-the-art facility. The position requires hands-on laboratory work and collaboration across multiple departments.

Key Responsibilities

• Develop and optimize synthetic routes for APIs, focusing on scalability, safety, and cost-effectiveness.
• Conduct process hazard analyses and implement appropriate safety measures.
• Perform reaction kinetics studies and thermodynamic analysis to understand process behavior.
• Develop analytical methods for monitoring reaction progress and product quality.
• Scale-up chemical processes from laboratory to pilot plant and commercial manufacturing.
• Troubleshoot process deviations and implement corrective actions.
• Collaborate with engineers, analytical chemists, and regulatory affairs specialists.
• Ensure all activities comply with cGMP and other relevant regulatory requirements.

Requirements

• MSc or Ph.D. in Organic Chemistry, Process Chemistry, or a related field.
• Minimum of 5 years of experience in pharmaceutical process development.
• Strong knowledge of organic synthesis, reaction mechanisms, and purification techniques.
• Experience with process scale-up, pilot plant operations, and technology transfer.
• Familiarity with Process Analytical Technology (PAT) and Quality by Design (QbD) principles.
• Proficiency in analytical techniques such as HPLC, GC, NMR, and MS.
• Excellent problem-solving and analytical skills.
• Strong written and verbal communication skills, with the ability to document work thoroughly.

Benefits

Our client offers a competitive salary, annual bonus, and a comprehensive benefits package including medical aid, retirement fund, and life insurance. We provide opportunities for continuous professional development, including training courses and attendance at industry conferences. The role is based in our modern facility in Bloemfontein , offering a dynamic and collaborative work environment. This is an on-site position.