Senior Process Chemist - Pharmaceutical Development

Placements24; Vereeniging; Presencial; ZAR 900.000 - 1.300.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Competitive salary

Health insurance

Retirement plan

Generous leave

Professional development

On-site cafeteria

Descripción de la vacante

Placements24 is seeking a Senior Process Chemist for our pharmaceutical development facility in Vereeniging, Gauteng. You will lead API process development, optimize routes, and scale from lab to pilot and commercial production, ensuring GMP compliance.

The role requires a PhD or MSc in Organic Chemistry, Process Chemistry, or Chemical Engineering with 5+ years in pharma process development, strong DoE and process safety expertise, and excellent collaboration across analytical, formulation and

Formación

• Ph.D. or master's degree in Organic Chemistry, Process Chemistry or Chemical Engineering.
• Minimum 5 years of pharmaceutical process development and scale-up experience.
• Strong knowledge of organic synthesis, reaction mechanisms, and purification techniques.
• Experience with DoE, process optimization, and process safety assessment.
• Familiarity with GMP regulations and ICH guidelines.
• Proficiency with analytical instrumentation for chemical characterization.
• Excellent problem-solving skills and hands-on approach.
• Strong written and verbal communication; ability to work in a multidisciplinary team.

Responsabilidades

• Develop and optimize synthetic routes for APIs and intermediates with focus on efficiency, safety and scalability.
• Conduct process research including parameter screening, DoE and kinetic studies.
• Scale up chemical processes from lab to pilot plant and commercial manufacturing.
• Troubleshoot and resolve technical issues in process development and manufacturing.
• Implement PAT and other advanced control strategies.
• Ensure all processes comply with GMP and regulatory guidelines.
• Perform PHAs and establish safe operating procedures.
• Characterize materials using analytical techniques (HPLC, GC, NMR, MS).
• Collaborate with analytical, formulation and engineering teams for project progression.

Conocimientos

Organic synthesis

Reaction mechanisms

Purification techniques

Process optimization

DoE

Process safety assessment

GMP compliance

Educación

Ph.D./MSc in Organic Chemistry, Process Chemistry or Chemical Engineering

Herramientas

Analytical instrumentation

Descripción del empleo

About the Role

Our client, a rapidly expanding pharmaceutical company dedicated to developing life-changing medications, is seeking a highly skilled Senior Process Chemist to join their dynamic Pharmaceutical Development division. This crucial role is situated at our modern research and manufacturing facility in Vereeniging, Gauteng . You will be instrumental in the development, optimization, and scale-up of robust and efficient chemical processes for active pharmaceutical ingredients (APIs). This position offers a significant opportunity to contribute to bringing innovative therapies from the laboratory to patients. You will lead process research projects, troubleshoot existing manufacturing issues, and ensure adherence to stringent regulatory standards. We are looking for a motivated and experienced chemist with a deep understanding of organic synthesis, reaction kinetics, and process safety. Your expertise in translating laboratory-scale reactions to pilot and commercial production will be essential. This is an excellent career opportunity to make a tangible impact in the pharmaceutical industry within a collaborative and forward-thinking organization.

Key Responsibilities

• Develop and optimize synthetic routes for APIs and intermediates, focusing on efficiency, safety, and scalability.
• Conduct process research, including parameter screening, DoE (Design of Experiments), and kinetic studies.
• Scale up chemical processes from laboratory to pilot plant and commercial manufacturing.
• Troubleshoot and resolve technical issues encountered during process development and manufacturing.
• Implement Process Analytical Technology (PAT) and other advanced control strategies.
• Ensure all processes comply with Good Manufacturing Practices (GMP) and relevant regulatory guidelines.
• Perform process hazard analyses (PHAs) and ensure safe operating procedures are in place.
• Characterize raw materials, intermediates, and final products using analytical techniques (e.g., HPLC, GC, NMR, MS).
• Collaborate with analytical, formulation, and engineering teams to ensure seamless project progression.

Requirements

• Ph.D. or Master's Degree in Organic Chemistry, Process Chemistry, or Chemical Engineering.
• Minimum of 5 years of experience in pharmaceutical process development and scale-up.
• Strong knowledge of organic synthesis, reaction mechanisms, and purification techniques.
• Experience with process optimization, DoE, and process safety assessment.
• Familiarity with GMP regulations and ICH guidelines.
• Proficiency with analytical instrumentation for chemical characterization.
• Excellent problem-solving skills and a hands-on approach.
• Strong written and verbal communication skills.
• Ability to work effectively in a multidisciplinary team environment.

Benefits

• Competitive salary package and annual performance bonus.
• Comprehensive health insurance and retirement plan.
• Generous annual leave and sick leave benefits.
• Opportunities for professional development and further education.
• Access to advanced laboratory and pilot plant facilities.
• A collaborative and innovative work culture.
• Contribution to groundbreaking pharmaceutical research.
• On-site cafeteria and wellness programs.