Upstream Process Engineer II — AAV Gene Therapy

Regeneron Pharmaceuticals, Inc.; Tarrytown (GA); On-site; USD 96,000 - 156,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. seeks a Process Development Engineer II to advance upstream viral vector production for GMP clinical and commercial pipelines.

You will lead seed train and bioreactor design, perform multivariate optimization, and collaborate closely with multi-disciplinary teams across development stages. The role emphasizes strong experimental design, data interpretation, and dissemination of findings.

Qualifications

• BS or MS in a related field with relevant experience.
• Experience with HEK cell culture and AAV-based production.
• Experience in bioprocess development and tech transfer is preferred.

Responsibilities

• Design seed train and bioreactor processes for upstream viral vector production.
• Lead studies to optimize transfection, bioreactor, and scale-up parameters.
• Act as upstream SME and lead technology transfer to clinical manufacturing.
• Conduct development studies to improve viral vector production and assay screening.
• Support next-gen suspension lentiviral vector production projects.
• Lead and participate in data management initiatives within the team.

Skills

AAV production

Upstream bioprocessing

Design of experiments

Cell culture (HEK)

Scale-up

Data analysis

Communication skills

Education

Bachelor's degree in Chemical/Biochemical Engineering or related field

Master's degree in Chemical/Biochemical Engineering or related field

Tools

BioProfile FLEX2

AMBR250

Benchling

JMP

Bench-top bioreactors

Pi Historian

Job description

Regeneron Pharmaceuticals, Inc. seeks a Process Development Engineer II to advance upstream viral vector production for GMP clinical and commercial pipelines.

You will lead seed train and bioreactor design, perform multivariate optimization, and collaborate closely with multi-disciplinary teams across development stages. The role emphasizes strong experimental design, data interpretation, and dissemination of findings.