AAV Upstream Process Engineer II – Gene Therapy

BioSpace; Village of Tarrytown (NY); Sur place; USD 96 000 - 156 000; Plein temps

Résumé du poste

Regeneron is seeking a Process Development Engineer II for its PMPD group in Tarrytown, NY. You will design and optimize seed train and bioreactor processes for AAV production, lead DOE studies, and drive technology transfer to clinical manufacturing for gene therapy programs.

The role requires strong experimental and analytical skills, collaboration across teams, and a proactive growth mindset in a dynamic pipeline environment.

Qualifications

• Bachelor’s or Master’s degree in Chemical/Biochemical Engineering, Biochemistry or related field with 4–8+ years of relevant experience.
• Solid experience with HEK mammalian cell culture and AAV-based gene therapy vector production.
• Experience with bioreactor scale-up and technology transfer preferred.
• JMP experience preferred; lentiviral vector production a plus.
• Proven ability to design experiments and interpret results with clear documentation.

Responsabilités

• Design optimized, well-characterized seed train and bioreactor processes for upstream viral vector production in suspension cell lines, suitable for GMP clinical and commercial production.
• Lead studies to optimize transfection, bioreactor, and scale-up parameters for viral production using multivariate DOE approaches.
• Serve as upstream SME and lead technology transfer to clinical manufacturing for future gene therapy programs.
• Conduct technology development to enhance process understanding, including reagent screening, equipment evaluation, plasmid system improvements, stable producer cell line development, and perfusion process development.
• Support development of next-generation suspension lentiviral vector production in collaboration with Regeneron Cell Medicine colleagues.
• Lead and support ongoing data management initiatives within the team.

Connaissances

Strong experimental skills

Analytical mindset

Excellent communication

Growth mindset

Team collaboration

Formation

Bachelor's or Master's in Chemical Engineering, Biochemical Engineering, Biochemistry or related field

Outils

JMP

Benchling

BioProfile FLEX2

AMBR250 bioreactors

Bench top bioreactors

Single-use pilot scale bioreactors (50-500 L)

Wave rockers

Biosafety cabinets

Incubators

Autoclave

Pi Historian

Description du poste

Regeneron is seeking a Process Development Engineer II for its PMPD group in Tarrytown, NY. You will design and optimize seed train and bioreactor processes for AAV production, lead DOE studies, and drive technology transfer to clinical manufacturing for gene therapy programs.

The role requires strong experimental and analytical skills, collaboration across teams, and a proactive growth mindset in a dynamic pipeline environment.