Upstream Process Development Associate II

Sarepta Therapeutics; Columbus (OH); On-site; USD 70,000 - 88,000; Full time

Benefits offered by this job

Physical and Emotional Wellness

Financial Wellness

Caregiver support

Job summary

Sarepta Therapeutics seeks a Research Associate I/II, Early Stage Process Development, to support upstream processes for siRNA and AAV vectors. You will work closely with Downstream, Analytical, and Vector Core groups to deliver robust manufacturing processes.

On-site role in the United States with emphasis on biochemistry, cell biology and engineering expertise. The position focuses on experimental design, data generation, and cross-functional collaboration to drive early-stage development and

Qualifications

• B.S. in Bioengineering, chemical/biochemical engineering, biology or related field with 2–4 years of experience or M.S. with 0–2 years.
• Experience in mammalian cell culture techniques and aseptic processing.
• Experience in upstream techniques for biologics production (AAV, Lenti vectors) is a plus.
• Experience with basic biochemistry lab techniques (qRT‑PCR, SDS‑PAGE, Western blot, ELISA).
• Ability to troubleshoot, manage projects, and communicate results clearly.
• Self-motivated, ownership mindset and ability to adapt to shifting priorities.

Responsibilities

• Design, plan and execute experiments to support development and production efforts.
• Work with mammalian suspension cell lines using shake flasks and bioreactors.
• Lead maintenance and operation of platforms like ambr15/ambr250 and small-scale bioreactors.
• Analyze in-process samples and materials.
• Document work in electronic lab notebook and communicate results.
• Collaborate with cross-functional teams to advance production activities.
• Maintain lab instrumentation and materials; perform related duties as required.

Skills

Cell culture techniques

Troubleshooting

Communication skills

Project management

Adaptability

Team collaboration

Education

B.S. in Bioengineering or related

M.S. in related field considered

Tools

ambr15

ambr250

bioreactors

SDS-PAGE

Western blot

ELISA

qRT-PCR

Job description

Sarepta Therapeutics seeks a Research Associate I/II, Early Stage Process Development, to support upstream processes for siRNA and AAV vectors. You will work closely with Downstream, Analytical, and Vector Core groups to deliver robust manufacturing processes.

On-site role in the United States with emphasis on biochemistry, cell biology and engineering expertise. The position focuses on experimental design, data generation, and cross-functional collaboration to drive early-stage development and