Translational Biomarkers Lead — Clinical

Vividion Therapeutics, Inc.; San Diego (CA); On-site; USD 200,000 - 270,000; Full time

Job summary

Vividion Therapeutics, Inc. in San Diego seeks a translational medicine leader to champion bidirectional translational medicine across discovery and clinical development, guiding biomarker strategies and mechanistic hypotheses to accelerate first-in-class programs.

You will lead multidisciplinary teams, integrate clinical and preclinical data, and contribute to regulatory submissions while shaping the portfolio strategy and target product profiles.

Qualifications

• Advanced degree in oncology, immunology, molecular biology, pharmacology or related field; M.D., M.D./Ph.D., or Ph.D. preferred.
• 8–12+ years of leadership in translational medicine and early clinical development in biotech/pharma.
• Deep oncology domain knowledge; immunology desirable; experience with small molecules or novel mechanisms advantageous.

Responsibilities

• Lead integrated translational medicine strategies across discovery, IND-enabling, and clinical-stage programs.
• Define translational plans to maximize technical, clinical, and regulatory success for first-in-class assets.
• Establish milestones from target validation to clinical proof-of-concept; drive iterative bench-to-bedside learning.
• Direct reverse translational efforts by translating clinical observations into preclinical hypotheses.
• Collaborate with discovery and regulatory teams to design translational endpoints and model-informed development plans.
• Lead multidisciplinary data review meetings to integrate biomarker, imaging, genomic, and pharmacology data for development decisions.

Skills

Leadership

Translational medicine

Biomarker strategy

Cross-functional collaboration

Data interpretation

Regulatory fluency

R Programming

Python

Genomics analysis

Education

Advanced degree in oncology, immunology, molecular biology, pharmacology (M.D., M.D./Ph.D., or Ph.D. preferred)

Tools

R Programming

Python

Job description

Vividion Therapeutics, Inc. in San Diego seeks a translational medicine leader to champion bidirectional translational medicine across discovery and clinical development, guiding biomarker strategies and mechanistic hypotheses to accelerate first-in-class programs.

You will lead multidisciplinary teams, integrate clinical and preclinical data, and contribute to regulatory submissions while shaping the portfolio strategy and target product profiles.