Strategic Lead, Bispecific Antibody Design & Engineering

Regeneron Pharmaceuticals, Inc.; United States; On-site; USD 180,000 - 280,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. in Tarrytown, NY is seeking a Senior Principal Scientist to lead a small team in Bispecific Antibodies, integrating structural insight with AI/ML-enabled design and high-throughput validation to advance next‑generation therapeutics.

You will guide design strategies, oversee expression and assays, build design rules, and mentor scientists. Strong leadership and collaboration with biology and computational teams are essential to drive programs from concept to IND.

Qualifications

• PhD in Structural Biology, Biochemistry, Biophysics, Protein Engineering, Computational Biology, Immunology, or related field.
• 8+ years post‑PhD experience in biotech/pharma.
• At least 2 years direct people management with a track record developing scientists.
• Experience engineering bispecific or multispecific antibody formats.
• Hands‑on cloning, protein expression, purification, and biophysical characterization.
• Experience with mammalian cell culture and cell‑based assays.

Responsibilities

• Set molecular design strategy for bispecific and multispecific antibodies based on target biology, structure, and mechanism of action.
• Lead structure‑guided design of novel formats, including binding‑arm selection, epitope and geometry optimization, and chain pairing.
• Drive protein engineering campaigns that integrate AI/ML and in silico design into iterative design‑build‑test‑learn cycles.
• Oversee high‑throughput construct generation, expression, purification, biophysical characterization, and cell‑based functional assays.
• Build curated engineering datasets and design rules to strengthen the bispecific platform across oncology, immunology, and infectious disease.
• Lead, mentor, and develop a team of scientists, partnering with internal and external groups.
• Apply structural biology to solve hard antibody and protein engineering problems, combining experimental data with computational design.
• Lead multiple projects in parallel with strong organization and ability to communicate to non‑specialists.

Skills

bispecific antibodies

structure-guided design

AI/ML

protein engineering

mammalian cell culture

team leadership

Education

PhD in Structural Biology, Biochemistry, Biophysics, Protein Engineering, Computational Biology, Immunology, or related field

Tools

AlphaFold

Rosetta

MOE

PyMOL

Job description

Regeneron Pharmaceuticals, Inc. in Tarrytown, NY is seeking a Senior Principal Scientist to lead a small team in Bispecific Antibodies, integrating structural insight with AI/ML-enabled design and high-throughput validation to advance next‑generation therapeutics.

You will guide design strategies, oversee expression and assays, build design rules, and mentor scientists. Strong leadership and collaboration with biology and computational teams are essential to drive programs from concept to IND.