Lead Scientist & Group Leader, Antibody Engineering

Genentech; San Francisco (CA); On-site; USD 158,000 - 263,000; Full time

Benefits offered by this job

Relocation benefits

Job summary

Genentech's Antibody Engineering department seeks a visionary Principal Scientist to lead a bench-based lab team advancing molecular formats and translating exploratory biology into transformational medicines for patients.

You will collaborate across Discovery Biology, Structural Biology, Translational Science and Technical Development to de-risk platforms, define molecular requirements for projects, and drive innovation toward next-generation therapeutics while fostering an inclusive lab

Qualifications

• PhD required or applicants from postdoctoral positions.
• Demonstrated expertise in both protein engineering and biology.
• Foundational understanding of protein stability and protein-protein interactions with methods for their characterization.
• Sustained productivity with publications, patents, or external presentations.

Responsibilities

• Direct and manage a bench-focused laboratory team, fostering technical growth, innovative research, and effective execution.
• Advance internal technological capabilities by developing novel methods and predictive assays to de-risk emerging therapeutic formats.
• Define molecular requirements for therapeutic projects and lead cross-functional teams to identify and advance next-generation clinical candidates.
• Drive platform innovation across emerging biotherapeutic mechanisms, potentially including induced proximity, receptor agonism, targeted therapeutics, or ADCs.
• Cultivate an inclusive, high-performing lab culture built on curiosity, scientific rigor, and open communication.
• Collaborate closely with multidisciplinary research partners across Discovery Biology, Structural Biology, Translational Science, and Technical Development to integrate biological activity with clinical manufacturability.

Skills

Protein engineering

Biology

Communication skills

Collaboration

Education

PhD in biochemistry, chemical biology, structural biology, or related field

Job description

Genentech's Antibody Engineering department seeks a visionary Principal Scientist to lead a bench-based lab team advancing molecular formats and translating exploratory biology into transformational medicines for patients.

You will collaborate across Discovery Biology, Structural Biology, Translational Science and Technical Development to de-risk platforms, define molecular requirements for projects, and drive innovation toward next-generation therapeutics while fostering an inclusive lab