Lead Scientist, Antibody Engineering & AI for Biologics

SystImmune, Inc.

Bothell (WA)

On-site

USD 130,000 - 160,000

Full time

5 days ago
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Benefits offered by this job

Health insurance
401(k) with match
PTO 15 days
Paid holidays
Sick leave

Job summary

SystImmune, Inc. in Bothell, WA is seeking a Principal Scientist to lead protein engineering efforts for therapeutic antibodies, including bispecifics and ADCs.

This role emphasizes data analysis, project management, and driving decisions to advance programs. The ideal candidate has 8+ years in industry, a PhD in biochemistry/biophysics or related field, deep antibody engineering expertise, and experience with AI/ML tools.

Qualifications

  • Eight-plus years of industry experience in antibody engineering or related biotherapeutics.
  • Deep expertise in designing and optimizing therapeutic antibody candidates.
  • Proven ability to lead projects and manage timelines in fast-paced environments.
  • Strong data analysis skills and experience with AI/ML tools for protein engineering.

Responsibilities

  • Lead and advance antibody engineering projects, coordinating cross-functional teams.
  • Apply deep engineering expertise to design and optimize bispecific/multi-specific formats.
  • Drive data-driven decisions and report results to leadership.
  • Mentor junior scientists and oversee lab operations and safety.

Skills

Antibody engineering
Data analysis
AI/ML
Protein purification
Team leadership
Experimental design

Education

PhD in biochemistry / biophysics / molecular biology / structural biology / cell biology

Tools

FPLC
HPLC
BLI/SPR
DLS/SLS
LIMS
PCR / DNA sequencing

Job description

SystImmune, Inc. in Bothell, WA is seeking a Principal Scientist to lead protein engineering efforts for therapeutic antibodies, including bispecifics and ADCs.

This role emphasizes data analysis, project management, and driving decisions to advance programs. The ideal candidate has 8+ years in industry, a PhD in biochemistry/biophysics or related field, deep antibody engineering expertise, and experience with AI/ML tools.

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