Sr Scientist, Translational Biomarkers

Arrowhead Pharmaceuticals; Madison (WI); On-site; USD 120,000 - 140,000; Full time

Job summary

An innovative biopharmaceutical company is seeking a Senior Scientist to lead the development of clinical biomarker strategies. This role demands a strong background in translational research and excellent communication skills. The successful candidate will design and execute robust biomarker assays, collaborate with various teams, and mentor junior scientists. This position offers the opportunity to work on cutting-edge therapies that address intractable diseases. Join a dynamic team dedicated to making a significant impact in the field of medicine and contribute to groundbreaking advancements in RNA interference technologies.

Qualifications

• PhD and at least 5 years of experience in translational biomarker technologies.
• Extensive experience in biomarker assay development and validation.

Responsibilities

• Design and execute clinical biomarker assays for drug development.
• Collaborate in a matrixed organization to advance early-stage projects.

Skills

Translational research

Clinical biomarkers

Problem-solving

Excellent communication

Organizational skills

Education

PhD in Biological Sciences

Tools

LC/MS

Job description

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Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Senior Scientist will be part of a team responsible for executing translational biomarker strategies for drug development candidates. This role requires a strong background in the biological sciences, with deep experience in translational research, medicine, and clinical biomarkers in drug development. Success in this position also depends on excellent communication skills, the ability to thrive in a fast-paced, matrixed environment, strong problem-solving capabilities, and a commitment to excellence.

Responsibilities

• Design, develop, and execute robust “fit-for-purpose” clinical biomarker assays to support the evaluation of pharmacodynamics, and prediction of clinical response from early discovery to first in human proof of concept.
• Identify and evaluate new technologies to support our evolving translational biomarker strategies.
• Partner with outsourcing functions to evaluate new CROs, drive transitioning and monitoring of internally developed assays to external vendors.
• Effectively collaborate in a highly matrixed organization to drive advancement of early-stage projects into translational and clinical development.
• May lead Associate Scientists as a manager or mentor.
  
  

Requirements

• PhD and at least 5 or more years of industrial experience applying translational biomarker technologies for discovery and/or clinical research.
• Extensive experience in technical development, validation, and implementation of cellular and soluble biomarker assays in clinical studies.
• Extensive experience in LC/MS assay development, validation, and implementation in clinical studies.
• Excellent organization skills and familiarity with a fast-paced work environment.
• Collaborative spirit and ability to thrive in a matrixed environment.
  
  

Wisconsin pay range

$120,000—$140,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

California Applicant Privacy Policy

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

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