Director/Senior Director - New Target Validation

BioSpace; Indianapolis (IN); On-site; USD 153,000 - 264,000; Full time

Benefits offered by this job

Bonus

Comprehensive benefits

401(k) and pension

Vacation benefits

Job summary

Lilly Immunology is seeking a Director/Senior Director for New Target Validation within Discovery Immunology in Indianapolis. You will guide the biological strategy and translational readiness for projects, leading target identification through mechanistic validation and cross‑functional collaboration with internal teams, CROs, and academic partners.

The role requires a Ph.D. in Molecular Genetics and Immunology and 8–10 years of drug development experience, including work on autoimmune

Qualifications

• Required: Ph.D. in Molecular Genetics and Immunology.
• 8–10 years of drug development experience, with a strong focus including research on asthma, atopic dermatitis, and rheumatologic diseases.

Responsibilities

• Define and lead end-to-end strategy for new target validation, spanning genetic perturbation, pathway deconvolution, cellular pharmacology, and translational model design.
• Drive innovation through development of novel human systems for target validation (Organs‑on‑chip, ex vivo models, IPSC, HSC engineering).
• Integrate multimodal profiling (imaging, transcriptomics, cytokine and proteomics) to strengthen human disease relevance and predictive validity.
• Communicate workplans that drive scientific decision-making across multidisciplinary teams and ensure robust rationale and data-supported progression criteria.
• Train discovery biologists in molecular biology designs and building functional assays.
• Guide cross-functional project teams through influence across a matrixed organization.

Skills

Target validation strategy

Translational immunology

Leadership

Data interpretation

Education

PhD in Molecular Genetics and Immunology

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Position Overview

Lilly Immunology is a therapeutic area focused on many autoimmune diseases spanning gastroenterology, dermatology and rheumatology. We are seeking an accomplished and influential Director / Senior Director for New Target Validation within Discovery Immunology. The key responsibility would be to guide biological strategy and translational readiness for projects and to steer target identification through mechanistic validation. The ideal candidate is a seasoned drug developer who advances new target validation by working through and with others—partnering across internal functions and external collaborators (CROs, academic groups, and technology partners)—while bringing deep scientific judgment in functional genomics, phenotypic and mechanistic discovery, and physiologically relevant primary human model systems.

This role provides scientific and strategic leadership—leading through influence and communicating effectively upward to senior management and governance—across cross‑functional discovery teams, building the workplans and data packages that enable confident target nomination, modality selection, and early portfolio advancement in immunology.

Key Objectives/Deliverables

• Define and lead the end‑to‑end strategy for new target validation, spanning genetic perturbation, pathway deconvolution, cellular pharmacology, and translational model design.
• Drive innovation through the development of novel human systems for target validation (Organs‑on‑chip, ex vivo human model systems, IPSC, HSC engineering)
• Integrate multimodal profiling (imaging, transcriptomics, cytokine and proteomics readouts) generated across internal and external partners to strengthen human disease relevance and predictive validity.
• Communicate workplans that drive scientific decision‑making across multidisciplinary project teams to ensure robust biological rationale, mechanism‑of‑action understanding, and data‑supported progression criteria.
• Train discovery biologists in molecular biology designs and building functional assays.
• Guide cross‑functional project teams through influence across a matrixed organization.

Qualifications

• Required : Ph.D. in Molecular Genetics and Immunology
• 8–10 years of drug development experience, with a strong focus including research on asthma, atopic dermatitis, and rheumatologic diseases.

Prefered

• Demonstrated leadership in developing high‑performing teams by coaching, mentoring, and empowering diverse talent to grow in capability, influence, and leadership impact.
• Proven track record of generating data packages that increase mechanism‑of‑action confidence, target engagement requirements for advancing validated targets into lead generation/candidate selection.
• Strong interpersonal skills and a demonstrated ability to make data‑driven decisions and find innovative solutions to overcome scientific and operational obstacles within matrix environment
• Excellent written and verbal communication skills, including the ability to communicate upward to senior leadership and governance and to present complex scientific data to diverse audiences.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$153,000 - $264,000

Full‑time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

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