Executive Medical Director - Physician -Early Clinical Development, Immunology

Eli Lilly and Company; Indianapolis (IN); On-site; USD 250,000 - 380,000; Full time

Job summary

Lilly is seeking an Executive Medical Director, Early Clinical Development in its Immunology Discovery group. The role leads translational strategies for autoimmune and inflammatory diseases, guiding hypotheses and early trials from concept through first-in-human, with global regulatory collaboration.

Based in the U.S. with 25–40% travel, the role reports to the Head of Early Clinical Development, Immunology Discovery, and collaborates across discovery, translational medicine, pharmacology,

Qualifications

• MD or DO
• Board eligible/certified in Rheumatology, Dermatology, or related specialty
• 3–5+ years pharma/biotech experience in early clinical development
• Strong background in immunology, translational medicine, and clinical trial design

Responsibilities

• Develop and refine therapeutic hypotheses
• Oversee early-phase clinical studies
• Integrate translational biomarkers
• Contribute to regulatory strategies
• Influence portfolio direction through cross-functional collaboration

Job description

Role

Executive Medical Director, Early Clinical Development in Lilly's Immunology team, leading translational strategies for autoimmune and inflammatory diseases.

Responsibilities

• develop and refine therapeutic hypotheses
• oversee early-phase clinical studies
• integrate translational biomarkers
• contribute to regulatory strategies
• influence portfolio direction through cross-functional collaboration

Requirements

• MD or DO
• board eligible/certified in Rheumatology, Dermatology, or related specialty
• 3–5+ years pharma/biotech experience in early clinical development
• strong background in immunology, translational medicine, and clinical trial design

Preferred

• PhD in Immunology or related field
• proven leadership in early-phase trials
• expertise with biologics and novel immunomodulatory approaches
• experience with regulatory interactions
• track record of scientific publications

High-Value

• autoimmune/inflammatory indications
• early clinical phase (FIH to proof-of-concept)
• biomarker strategies
• global regulatory engagement
• influence in immunology innovation

Location

Boston, San Diego, San Francisco, or Indianapolis, with 25-40% travel.

Reports to

Head of Early Clinical Development, Immunology Discovery.

Collaboration

Extensive matrix across discovery, translational medicine, pharmacology, regulatory, and business development teams.

Work setup

Full-time role with significant leadership and strategic influence in a rapidly expanding Lilly Immunology organization.