Senior Translational Pharmacologist, ADC & RLT (Remote)

Clora; Boston (MA); A distancia; USD 241.000 - 434.000; A tiempo parcial

Descripción de la vacante

Clora is seeking an experienced translational pharmacologist to advance ADC and radioligand therapy programs toward clinical development. The role is remote and spans leadership of PK/PD strategies across preclinical teams and CRO partners.

The ideal candidate holds a PhD with 10+ years in Biotech/Biopharma, with deep expertise in biologics PK/PD and oncology translational pharmacology, and a background in radiopharmaceuticals or dosimetry is a plus.

Formación

• PhD or equivalent in pharmacology or related field.
• 10+ years of industry experience in Biotech/Biopharma.
• Expertise in biologics PK/PD, oncology translational pharmacology, and ADC development.
• Experience with radiopharmaceuticals, dosimetry, or quantitative systems pharmacology is desirable.

Responsabilidades

• Lead translational PK/PD strategy integrating efficacy, biodistribution, exposure, and toxicology data.
• Develop exposure-response relationships and translational models to support clinical dose selection and therapeutic index projections.
• Guide preclinical study design, including dose optimization, scheduling, and pharmacology studies supporting IND-enabling development.
• Integrate mouse and nonhuman primate data to inform human PK projections and first-in-human dosing strategies.
• Work closely with internal scientists and external CROs to interpret results and identify critical development experiments.

Conocimientos

Translational PK/PD

Oncology translational pharmacology

ADC development

Biologics PK/PD

Dose optimization

Educación

PhD in pharmacology

Descripción del empleo

Clora is seeking an experienced translational pharmacologist to advance ADC and radioligand therapy programs toward clinical development. The role is remote and spans leadership of PK/PD strategies across preclinical teams and CRO partners.

The ideal candidate holds a PhD with 10+ years in Biotech/Biopharma, with deep expertise in biologics PK/PD and oncology translational pharmacology, and a background in radiopharmaceuticals or dosimetry is a plus.