Senior Translational Data Scientist – Oncology & Biomarkers

Parabilis Medicines; Cambridge (MA); On-site; USD 215,000 - 245,000; Full time

Job summary

Parabilis Medicines in Cambridge, MA seeks a senior Translational Data Scientist to lead computational biology efforts across preclinical projects, target identification, and biomarker strategy.

You will translate complex multi-omic data into clear, decision-ready insights, collaborate with discovery biology, pharmacology, and clinical teams, and mentor colleagues while advancing data-driven drug discovery.

Qualifications

• PhD with 10+ years of industry experience in computational biology or related field.

Responsibilities

• Lead computational analyses supporting target identification and credentialing using tumor genomics, transcriptomics, functional genomics, human genetics, single-cell/spatial data, and clinical datasets.
• Analyze internal in vitro and in vivo studies to characterize target engagement, mechanism of action, response determinants, and resistance mechanisms.
• Integrate preclinical findings with human disease data to refine indication, patient-selection, biomarker, and combination hypotheses.
• Develop predictive and pharmacodynamic biomarker hypotheses that can be translated from Projects into Programs.
• Design statistically rigorous, reproducible analyses across multimodal oncology datasets, including DNA sequencing, bulk and single-cell RNA-seq, functional genomic screens, imaging, and other emerging data types.
• Distinguish exploratory findings from evidence sufficient to drive decisions and identify additional analyses or experiments needed to resolve key uncertainties.
• Present concise, decision-oriented recommendations to scientific teams, leadership, and governance.
• Advance computational approaches and best practices across Translational Data Science and provide scientific and technical mentorship to colleagues.

Skills

Python

R

Multimodal data integration

Leadership

Communication

AI tooling in science

Oncology drug discovery

Education

PhD in Computational Biology or related field

Tools

Genomics analysis pipelines

Biostatistics software (R)

Job description

Parabilis Medicines in Cambridge, MA seeks a senior Translational Data Scientist to lead computational biology efforts across preclinical projects, target identification, and biomarker strategy.

You will translate complex multi-omic data into clear, decision-ready insights, collaborate with discovery biology, pharmacology, and clinical teams, and mentor colleagues while advancing data-driven drug discovery.