Senior Scientist, Clinical Biomarkers - Oncology

Parabilis Medicines; Cambridge (MA); On-site; USD 140,000 - 165,000; Full time

Benefits offered by this job

Annual bonus

Equity

Comprehensive benefits

Job summary

Parabilis Medicines in Cambridge, MA is seeking a Senior Scientist, Clinical Biomarkers to advance biomarker strategies across pre-IND to Phase 1/2 oncology trials. You will translate preclinical findings into clinically feasible assays and drive data-informed decisions with cross-functional teams.

You will shape the biomarker strategy for our Helicons program, leveraging spatial omics, NGS, and other technologies to inform patient selection and response monitoring within a collaborative

Qualifications

• PhD in Cancer Biology, Immunology, or related field.
• 5+ years total experience with at least 2+ years in industry biomarker research across pre-IND to Phase 1/2.
• Experience in preclinical oncology translational research.
• Knowledge of fit-for-purpose assay technologies for clinical studies.
• Experience with spatial omics, multiplex immunoassays, NGS, IHC, flow cytometry, ctDNA.
• Strong communication and collaboration across functions.
• Publication record in oncology/translational research.
• Experience using AI tools; basic proficiency expected.

Responsibilities

• Capture biomarkers identified in preclinical studies for clinical translation from pre-IND through Phase 1/2 programs.
• Develop and qualify fit-for-purpose clinical biomarker assays and vendors.
• Conduct hypothesis-driven analysis, interpretation, and presentation of clinical biomarker data.
• Collaborate with Data Science and Biology to support biomarker exploration and identification.
• Partner with Clinical Science, Clinical Operations, and Clinical Pharmacology to embed biomarker strategy into protocols.
• Monitor emerging biomarker literature and competitive landscape to guide strategy.

Skills

Biomarker research

Clinical translation

Data analysis

Communication

AI tools

Cross-functional collaboration

Publications

Education

PhD in Cancer Biology or Immunology

Tools

Spatial omics

NGS

IHC

Flow cytometry

Multiplex immunoassays

ctDNA

Job description

AboutParabilisMedicines

ParabilisMedicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets longconsidered undruggable.The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigationalmedicine,zolucatetide, is the first and only direct inhibitorof theβ-catenin:TCFinteraction,a central node in theWnt/β-catenin pathway that haseluded drug developersfor decades.Zolucatetideis being evaluated in the clinic across multipleWnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP)anda rangeofothersolid tumor indications. Beyondzolucatetide,Parabilisis advancing additionalHelicon-basedprograms focused on other challenging targetswhere we believeourmedicines could have life-altering impact. For more information, visit www.parabilismed.com or follow us on LinkedIn.

What’s the opportunity?

We are seeking a Senior Scientist, Clinical Biomarkers to execute biomarker strategies that carry our oncology programs from pre-IND through Phase 1/2 clinical trials. In this role, you will translate preclinical biomarker findings into clinically feasible strategies, select and qualify fit-for-purpose assays, and drive hypothesis-driven data analysis and interpretation to inform patient selection, mechanism of action, and response monitoring. You will collaborate closely with Data Science, Biology, Clinical Science, Clinical Operations, Clinical Pharmacology, to translate biological insights into actionable clinical decisions and external engagement (e.g., with investigators and partners).

This is an individual-contributor role well suited to a scientist who is ready to apply their preclinical translational background to clinical biomarker work, with support from senior team members and cross-functional partners including Clinical Science, Clinical Operations, and Clinical Pharmacology. In this role, you will have the opportunity to shape biomarker strategy across a growing oncology pipeline.

Key Responsibilities

• Capture key biomarkers identified in preclinical studies and assess their feasibility for clinical translation, from pre-IND through Phase 1/2 programs
• Develop or qualify and implement fit-for-purpose clinical biomarker assays and vendors, setting expectations for anticipated data readouts, interpretation, and delivery timelines
• Conduct hypothesis-driven analysis, interpretation, and presentation of clinical biomarker data in support of clinical decision-making and external engagement
• Establish and maintain strong collaborative relationships with Data Science and Biology colleagues to perform exploratory biomarker analysis and support novel biomarker identification
• Partner with Clinical Science, Clinical Operations, and Clinical Pharmacology to embed biomarker strategy into protocol design and study execution
• Track and interpret emerging biomarker literature and competitive landscape to inform biomarker strategy

What you’ll need to be successful:

• D. in Cancer Biology, Immunology, or a closely related field
• 5+ years of total experience with at least 2+ years of industry experience in biomarker research spanning pre-IND through Phase 1/2 clinical programs
• Prior experience in preclinical oncology translational research
• In-depth knowledge of fit-for-purpose assay technologies and their implementation in clinical studies
• Direct experience with established and evolving biomarker assay technologies (e.g., spatial omics, multiplex immunoassays, NGS, IHC, flow cytometry, ctDNA/liquid biopsy)
• Experience in clinical spatial omics assay design, execution, and downstream bioinformatics analysis (e.g., cell segmentation, spatial clustering), in collaboration with Data Science, is preferred
• Proven track record of delivering impactful clinical translational data in close collaboration, preferably in an industry setting
• Demonstrated ability to interpret complex biomarker datasets and translate findings into clinical/scientific recommendations
• Excellent written and verbal communication skills; experience presenting to cross-functional and external audiences
• Publication record in peer-reviewed oncology/translational research journals
• Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader indefying the limitations of current therapeutic modalities, and interdependent as a team as wework collaboratively to shiftdrug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $140,000-$165,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com