Sr Dir Preclinical & Translational PK/PD

Regeneron Pharmaceuticals, Inc.; Village of Tarrytown (NY); On-site; USD 250,000 - 380,000; Full time

Job summary

Regeneron in Tarrytown, NY is seeking a Senior Director to oversee PK and PK/PD strategies for early-stage drug discovery. You will influence research across multiple modalities and therapeutic areas, guiding translational PK/PD strategies and leading cross-functional teams.

The role requires a PhD with 12+ years in biotech/pharma, deep PK/PD expertise, and strong leadership in study planning and data interpretation. On-site leadership will be essential for program success.

Qualifications

• PhD in Pharmacology, Biology or Biochemistry with 12+ years in biotech/pharma.
• Deep knowledge of PK/PD and translational pharmacology.
• Proven leadership in study planning, data interpretation and cross-functional coordination.

Responsibilities

• Guide nonclinical and translational PK/PD study design and execution.
• Coordinate with Therapeutic Proteins, Assay Development, Preclinical Operations, and other teams.
• Analyze data, derive FIH dose predictions, and prepare regulatory documentation.

Skills

PK/PD expertise

Leadership

Data interpretation

Communication

Education

PhD in Pharmacology/Biology/Biochemistry

Tools

WinNonLin

Job description

Role

Senior Director overseeing PK and PK/PD strategies for early-stage drug discovery projects at Regeneron, influencing research and development across multiple therapeutic areas and modalities, including proteins, siRNA, CAR-T, and gene therapies.

Responsibilities

serve as a scientific expert on preclinical and translational PK/PD, guide study design, coordinate with internal teams (Therapeutic Proteins, Assay Development, Preclinical Operations, etc.), manage nonclinical PK/PD studies, analyze data, derive FIH dose predictions, and prepare regulatory documentation.

Requirements

PhD in Pharmacology, Biology, Biochemistry, with 12+ years in biotech/pharma, deep knowledge of PK/PD, proven leadership in study planning and data interpretation, strong communication skills, familiarity with PK/PD software (e.g., WinNonLin).

Preferred

experience with novel modalities such as siRNA, CRISPR therapeutics, or cell therapies.

High-Value

focus on early discovery, translational pharmacology, cross-functional collaboration, and regulatory support for innovative biologics and gene therapies.

Location

Tarrytown, NY, on-site with leadership responsibilities.