Senior Scientist, Translational Biology & Oligonucleotides

Flagship Pioneering; Cambridge (MA); On-site; USD 126,000 - 182,000; Full time

Benefits offered by this job

Free snacks

Community lunchroom

Collaborative team environment

Job summary

Flagship Pioneering is seeking a Senior Scientist to join its Discovery Biology team in Cambridge, MA. You will apply biochemistry, assay development, and tissue processing to advance oligonucleotide therapies, collaborating with in vivo pharmacology, NGS, and bioinformatics groups.

Management of CROs and cross-functional teamwork are essential. Ideal candidates hold a PhD in molecular biology, biochemistry, or a related field with 3+ years in discovery research, and demonstrated ability to

Qualifications

• PhD in molecular biology, biochemistry, drug discovery, or related field with 3+ years of industry experience in discovery research.
• Hands-on experience designing and interpreting complex in vitro/ex vivo workflows, including sample processing and assay development.
• Good understanding of in vivo experiments for drug discovery and development in mouse models.
• Familiarity with high-dimensional readouts such as NGS and proteomics.
• Hands-on experience with standard biochemical techniques and ability to troubleshoot complex workflows.
• Track record of working in multidisciplinary teams including biochemists, in vivo biologists, and bioinformaticians.
• Motivated team-player with strong organizational and written/verbal communication skills.

Responsibilities

• Drive translational platform innovation aligned with core strategic goals, focusing on biochemical assay development and tissue processing.
• Generate and develop enhanced oligonucleotides in different biological settings against diverse drug targets.
• Support the design of in vivo experiments based on protocols developed in vitro.
• Collaborate with biochemists, in vivo biologists, NGS scientists, and bioinformatics teams.
• Work with CROs conducting in vitro/in vivo experiments to identify new drug molecules.
• Generate rapid, accurate data to drive decision-making for platform and pipeline programs.
• Establish and refine workflows, SOPs, and documentation for experiments at scale.
• Clearly communicate experimental design, results, challenges, and next steps in meetings and with collaborators.

Skills

Molecular biology

Biochemistry

Assay development

In vitro workflows

In vivo mouse models

NGS

Proteomics

CRO management

Team collaboration

Scientific communication

Education

PhD in molecular biology, biochemistry, drug discovery

Job description

Flagship Pioneering is seeking a Senior Scientist to join its Discovery Biology team in Cambridge, MA. You will apply biochemistry, assay development, and tissue processing to advance oligonucleotide therapies, collaborating with in vivo pharmacology, NGS, and bioinformatics groups.

Management of CROs and cross-functional teamwork are essential. Ideal candidates hold a PhD in molecular biology, biochemistry, or a related field with 3+ years in discovery research, and demonstrated ability to