Biochemistry & Lead Discovery Scientist I

Pioneering Medicines; Cambridge (MA); On-site; USD 100,000 - 127,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Comprehensive benefits

Job summary

Flagship Pioneering is seeking an independent lab scientist to lead biochemical assay development and target engagement studies in our Biochemistry team in Cambridge, MA. This role focuses on small molecules and related modalities, informing hit-to-lead optimization and mechanism-of-action understandings.

You will collaborate closely with chemistry and biology to drive discovery and inform strategic decisions.

Qualifications

• MS or PhD in Biochemistry, Chemical Biology, Enzymology, or related field
• MS and at least 8 years of relevant academic or industry experience
• PhD and 0-2 years of relevant academic or industry experience
• Deep understanding of protein chemistry and biophysics, with hands-on experience with small-molecule compounds
• Demonstrated ability to develop and troubleshoot biochemical assays independently
• Excellent communication skills and cross-functional collaboration ability
• Ability to operate in a fast-paced environment with shifting priorities
• Experience working with CROs is a plus

Responsibilities

• Lead biochemical assay development to monitor protein/ligand and protein/protein interactions
• Apply readout technologies such as FP, FRET, NanoBRET, or NanoBiT across active programs
• Drive protein purification and QC processes to support discovery efforts
• Set up and run high-throughput assays, troubleshooting to keep programs moving
• Partner with CROs as needed to extend internal capacity
• Collaborate cross-functionally and contribute scientific input across multiple projects

Skills

Biochemistry

Biophysics

Assay design

Communication

Independence

Cross-functional work

Fast-paced environment

Education

MS or PhD in Biochemistry / Chemical Biology / Enzymology

MS with 8+ years experience

PhD with 0-2 years experience

Tools

FP

FRET

NanoBRET

NanoBiT

Job description

Flagship Pioneering is seeking an independent lab scientist to lead biochemical assay development and target engagement studies in our Biochemistry team in Cambridge, MA. This role focuses on small molecules and related modalities, informing hit-to-lead optimization and mechanism-of-action understandings.

You will collaborate closely with chemistry and biology to drive discovery and inform strategic decisions.