Lead Scientist, Molecular Glue & Proximity Therapeutics
Amgen
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Benefits offered by this job
Job summary
Amgen in Thousand Oaks, CA, is seeking a Principal Scientist to lead discovery at the intersection of chemical biology, induced proximity, and phenotypic drug discovery. You will drive molecular glue discovery in disease-relevant systems, combining phenotypic screening with mechanistic biology to uncover new therapeutic opportunities.
In IPP, you will contribute to advancing induced proximity strategies through integrated phenotypic and mechanism-driven approaches, mentoring colleagues and
Qualifications
- PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field with 2 years of industry experience
- MS in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field with 5 years of industry experience
- BS in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field with 7 years of industry experience
Responsibilities
- Lead discovery using phenotypic screening and chemical genetics to identify proximity-driven mechanisms
- Develop disease-relevant cellular models to uncover actionable biology
- Integrate chemical biology and mechanistic studies to translate phenotypic findings into drug discovery programs
- Contribute to a growing portfolio of induced proximity-based therapeutic opportunities
- Design and implement phenotypic screening strategies to enable discovery of molecular glues and proximity-based modulators
- Develop and apply disease-relevant cellular models to capture functional biology
- Build and optimize high-content and high-throughput assays, including imaging-based readouts
- Apply chemical genetics approaches to interrogate biological pathways and support target identification and validation
- Integrate chemical biology and mechanistic studies to elucidate compound mode of action
Skills
Education
Job description
Amgen in Thousand Oaks, CA, is seeking a Principal Scientist to lead discovery at the intersection of chemical biology, induced proximity, and phenotypic drug discovery. You will drive molecular glue discovery in disease-relevant systems, combining phenotypic screening with mechanistic biology to uncover new therapeutic opportunities.
In IPP, you will contribute to advancing induced proximity strategies through integrated phenotypic and mechanism-driven approaches, mentoring colleagues and
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