Principal Scientist - Lead Discovery & TPD Biochemistry

Amgen; Thousand Oaks (CA); On-site; USD 120,000 - 150,000; Full time

Benefits offered by this job

Retirement and Savings Plan

Medical, dental and vision coverage

Annual bonus program

Stock-based long-term incentives

Flexible work models

Job summary

Amgen is seeking a Principal Scientist to lead initiatives in Lead Discovery and Targeted Protein Degradation Biochemistry in Thousand Oaks, California. You will take charge of protein reagent generation and biochemical assay development aimed at advancing drug discovery campaigns.

The ideal candidate will have deep expertise in protein biochemistry and a track record in managing teams. You will contribute to the development of novel therapeutics while benefiting from a competitive salary and comprehensive benefits that foster professional growth.

Qualifications

• PhD in Biochemistry, Chemical Biology, or related with 2 years of relevant industry experience.
• Expertise in protein purification and biochemical assay development.
• Extensive experience across mammalian, insect, and microbial systems.

Responsibilities

• Lead protein expression, purification, and characterization strategies.
• Develop biochemical and biophysical assays for drug discovery.
• Provide scientific direction and mentorship to a small team.

Skills

Protein purification

Biochemical assay development

Target engagement

Protein expression

Biophysical approaches

Education

Doctorate degree (PhD) in relevant field

Master’s degree with 5 years experience

Bachelor’s degree with 7 years experience

Tools

TR-FRET/HTRF

Fluorescence polarization (FP)

AlphaLISA

BLI/SPR

Job description

Amgen is seeking a Principal Scientist to lead initiatives in Lead Discovery and Targeted Protein Degradation Biochemistry in Thousand Oaks, California. You will take charge of protein reagent generation and biochemical assay development aimed at advancing drug discovery campaigns.

The ideal candidate will have deep expertise in protein biochemistry and a track record in managing teams. You will contribute to the development of novel therapeutics while benefiting from a competitive salary and comprehensive benefits that foster professional growth.