Senior Scientist, siRNA Therapeutics — Preclinical Lead

Qilu Pharmaceuticals; Boston (MA); On-site; USD 120,000 - 170,000; Full time

Job summary

Qilu Pharmaceuticals is seeking highly motivated scientists with strong assay development expertise to advance RNA Therapy programs, including siRNA therapeutics for metabolic, liver, neurological, and ocular diseases.

The successful candidates will lead preclinical studies, develop cellular and biochemical assays, and collaborate with internal teams and external CRO partners to validate therapeutic targets.

Qualifications

• Ph.D. in Molecular Biology, Pharmacology, Neuroscience or related discipline with 3+ years industry experience or 5+ years postdoctoral experience.
• Experience with siRNA, ASO, or other oligonucleotide therapeutics is highly preferred.
• Hands-on experience with RT-qPCR, ELISA, Western blotting, mammalian cell culture, animal handling, tissue collection, and tissue processing is required.
• Preferred skills include primary neuronal cell culture, stem-loop qPCR, and rodent dosing techniques (tail vein, intracranial administration).

Responsibilities

• Lead and execute preclinical screening and evaluation of siRNA candidates to support lead identification and candidate selection through integrated in vitro and in vivo studies.
• Investigate target biology and mechanism of action; design and conduct proof-of-concept studies to validate therapeutic targets with internal and external collaborators.
• Develop, optimize, and implement cellular and biochemical assays to support drug discovery and preclinical research activities.
• Collaborate with cross-functional teams including chemistry, non-clinical development, and bioinformatics; coordinate with external CRO partners.
• Manage multiple projects and deliver high-quality results within established timelines.
• Present scientific findings to project teams and leadership; communicate across functions.
• Maintain compliance with SOPs and lab standards; provide guidance and training to junior team members as needed.

Skills

siRNA experience

oligonucleotide therapeutics

RT-qPCR

ELISA

Western blotting

mammalian cell culture

animal handling

tissue collection

tissue processing

dosing techniques (rodent)

Education

Ph.D. in Molecular Biology, Pharmacology, Neuroscience

Job description

Qilu Pharmaceuticals is seeking highly motivated scientists with strong assay development expertise to advance RNA Therapy programs, including siRNA therapeutics for metabolic, liver, neurological, and ocular diseases.

The successful candidates will lead preclinical studies, develop cellular and biochemical assays, and collaborate with internal teams and external CRO partners to validate therapeutic targets.