Senior Scientist, Single-Cell Genomics & RNA-Seq

AllSTEM Connections; Boston (MA); On-site; USD 79,000 - 83,000; Full time

Job summary

Eli Lilly's Cardiometabolic Research (CMR) team in Boston seeks a Senior Research Associate to advance RNA sequencing workflows, including bulk RNA-seq, scRNA-seq, and snRNA-seq library preparations, across multiple therapeutic areas.

The role emphasizes hands-on molecular biology, data QC, assay design support, data analysis, and cross-functional collaboration. This is a 12-month contractor assignment focused on high-quality data generation.

Qualifications

• B.S. and/or M.S. in biological or biochemical sciences (or a related field) with 3-5 years of laboratory research experience.
• Molecular biology mastery of nucleic acid extraction and purification, quantification, NGS library preparation/QC, and qPCR.
• Strong background in NGS technologies and their applications, including quantification, sequencing, and data QC (preferably Illumina). Direct experience with RNA-seq (bulk) and amplicon-seq.
• Direct experience with single-cell and single-nucleus RNA-seq library preparation is required. Candidates must be familiar with multiple scRNA-seq/snRNA-seq platforms (e.g., 10X Genomics Chromium, Illumina PIP-seq, ScaleBio, or Parse Biosciences).

Responsibilities

• Conduct RNA-seq, scRNA-seq, snRNA-seq, and other sequencing library preparations for CMR groups.
• Support assay design, optimization, validation, and data analyses.
• Design and execute molecular and cell biology experiments.
• Troubleshoot and analyze complex data in support of drug discovery projects.
• Present results and conclusions orally and in written form.
• Collaborate across teams to advance research goals.

Skills

Organizational skills

Time management

Communication skills

Education

B.S./M.S. in biology or related

Tools

10X Genomics Chromium

Illumina PIP-seq

ScaleBio

Parse Biosciences

Job description

Eli Lilly's Cardiometabolic Research (CMR) team in Boston seeks a Senior Research Associate to advance RNA sequencing workflows, including bulk RNA-seq, scRNA-seq, and snRNA-seq library preparations, across multiple therapeutic areas.

The role emphasizes hands-on molecular biology, data QC, assay design support, data analysis, and cross-functional collaboration. This is a 12-month contractor assignment focused on high-quality data generation.