Senior Scientist, Recombinant Peptide Bioprocess

AbbVie Inc.; Irvine (CA); Sur place; USD 110 000 - 209 000; Plein temps

Résumé du poste

AbbVie Inc. in Irvine, CA is seeking a Senior Scientist II to lead recombinant peptide bioprocess development, including expression strategy, host/clone screening, scale-up, and purification optimization.

The role requires strong hands-on experience in E. coli/yeast systems, fusion-tag strategies, and analytical data interpretation, with responsibilities spanning design, optimization, and cross-functional collaboration. Mentoring and contributions to publications are expected.

Qualifications

• PhD with 4+ years of relevant experience; master's with 10+ years; bachelor's with 12+ years.
• Hands-on experience in microbial physiology and recombinant expression systems, particularly E. coli and yeast.
• Ability to independently design, execute, and interpret critical experiments.
• Experience developing or optimizing expression processes for peptides, small proteins, or unstable products.
• Experience with strain or clone screening, fermentation, and process optimization; familiarity with bioreactors and scale-down approaches.
• Experience with preparative chromatography and peptide/protein purification, and peptide recovery and fusion-partner cleavage strategies.
• Strong experimental design, data interpretation, troubleshooting, scientific writing, and oral communication.
• Ability to manage multiple priorities in a matrixed cross-functional environment.

Responsabilités

• Lead recombinant peptide process-development activities, including expression strategy, host and clone screening, process optimization, and scale-up.
• Design and evaluate expression constructs and microbial hosts (E. coli and yeast) for peptide production.
• Develop and assess fusion-tag strategies (His-tag, GST, SUMO) to improve stability and recovery.
• Design and conduct clone-screening studies using microscale cultivation and parallel bioreactors.
• Develop and optimize peptide recovery processes, including lysis, inclusion-body processing, and cleavage.
• Troubleshoot peptide-specific challenges: aggregation, solubility, degradation, cleavage, impurities.
• Interpret analytical data (HPLC/UPLC/LC-MS) and collaborate with analytical teams on characterization.
• Evaluate emerging technologies, including genetic code expansion, for program needs.
• Apply AI/ML to analyze sequences, structures, and data for design and prioritization.
• Communicate plans, progress, and conclusions to teams and stakeholders.
• Mentor junior scientists and provide technical direction in peptide bioprocessing.
• Contribute to publications and conferences; manage priorities and timelines.

Connaissances

Microbial physiology

Recombinant expression systems

Experimental design

Data interpretation

Troubleshooting

Scientific writing

Oral communication

Mentoring

Project leadership

Formation

PhD in relevant field

Master's degree in relevant field

Bachelor's degree with 12+ years of experience

Outils

HPLC

UPLC

LC-MS

Bioreactors

Scale-up

Chromatography

Expression constructs

Description du poste

AbbVie Inc. in Irvine, CA is seeking a Senior Scientist II to lead recombinant peptide bioprocess development, including expression strategy, host/clone screening, scale-up, and purification optimization.

The role requires strong hands-on experience in E. coli/yeast systems, fusion-tag strategies, and analytical data interpretation, with responsibilities spanning design, optimization, and cross-functional collaboration. Mentoring and contributions to publications are expected.