Senior Scientist II: Recombinant Peptide Bioprocess Lead

AbbVie Inc.; Lake Forest (CA); Sur place; USD 150 000 - 190 000; Plein temps

Résumé du poste

AbbVie Inc. in Lake Forest, CA seeks a scientist to lead the development of microbial-based recombinant peptide production processes. You will guide expression-system design, host/clone screening, and scale-up while optimizing recovery and purification strategies.

The role requires hands-on expertise in E. coli/yeast, chromatography, and analytical methods, plus collaboration across cross-functional teams and mentorship of junior scientists.

Qualifications

• PhD with typically 4+ years of relevant experience, master’s degree with 10+ years or bachelor’s with 12+ years is required.
• Hands-on experience in microbial physiology and recombinant expression systems, particularly E. coli and/or yeast.
• Ability to independently design, execute, and interpret critical experiments.
• Experience developing or optimizing expression processes for peptides or small proteins.
• Familiarity with bioreactors and scale-down or parallel cultivation approaches.
• Experience with preparative chromatography and peptide/protein purification.
• Strong experimental design, data interpretation, and scientific communication.

Responsabilités

• Lead recombinant peptide process-development activities including expression strategy, host and clone screening, process optimization, and scale-up.
• Design and evaluate expression constructs and microbial hosts for peptide production.
• Develop and assess fusion-tag and carrier-protein strategies to improve peptide stability and recovery.
• Design and conduct clone-screening studies using microscale cultivation and parallel bioreactors.
• Develop and optimize peptide recovery processes including lysis and cleavage strategies.
• Interpret analytical results (HPLC/UPLC/LC-MS) to assess identity, mass, and purity.
• Collaborate with analytical teams and transfer technology across programs.
• Mentor junior scientists and contribute to publications and conferences.

Connaissances

Microbial physiology

Recombinant expression

E. coli

Yeast

Process development

Analytical methods

Formation

PhD in a relevant field

Outils

HPLC

UPLC

LC-MS

Description du poste

AbbVie Inc. in Lake Forest, CA seeks a scientist to lead the development of microbial-based recombinant peptide production processes. You will guide expression-system design, host/clone screening, and scale-up while optimizing recovery and purification strategies.

The role requires hands-on expertise in E. coli/yeast, chromatography, and analytical methods, plus collaboration across cross-functional teams and mentorship of junior scientists.