Senior Scientist – Reagent & Assay Development (NGS)

Roche Holding AG; Santa Clara (CA); On-site; USD 99,000 - 133,000; Full time

Job summary

Roche Holding AG in California seeks a Senior Scientist to lead reagent and assay development for next-generation sequencing applications. The role combines hands-on lab work, experimental design, data analysis, and troubleshooting to enhance reagent performance and manufacturability.

You will collaborate with automation, software, engineering, quality, and operations teams to support product development and transfer to manufacturing. Strong NGS experience and Python programming are preferred.

Qualifications

• Bachelor’s degree required with 5 years in NGS workflows or reagent/assay development in a product-development environment
• PhD preferred with 0–3 years NGS-related research or industry experience
• Proficiency in Python or similar programming language for data analysis and automation

Responsibilities

• Develop and optimize reagents and assays for NGS applications
• Collaborate with automation, software, engineering, quality, and operations teams
• Design, develop, validate, and transfer manufacturing processes for reagents
• Analyze data, generate reports, and present findings to project teams
• Ensure adherence to good laboratory practices and maintain equipment and records

Skills

NGS workflows

Molecular biology techniques

Python

Experiment design

Data analysis

Education

Bachelor's degree in Biological/Life Sciences/Chemistry/Biochemistry

PhD in molecular biology/biochemistry/chemistry/ genetics/ bioengineering (preferred)

Tools

Laboratory automation

Job description

Roche Holding AG in California seeks a Senior Scientist to lead reagent and assay development for next-generation sequencing applications. The role combines hands-on lab work, experimental design, data analysis, and troubleshooting to enhance reagent performance and manufacturability.

You will collaborate with automation, software, engineering, quality, and operations teams to support product development and transfer to manufacturing. Strong NGS experience and Python programming are preferred.