Senior Scientist, Protein Ensemble Dynamics to Function

Astera Institute; Emeryville (CA); Presencial; USD 200.000 - 250.000; Tempo integral

Benefícios oferecidos por esta vaga

Top-tier health insurance

Daily lunch

Licenses for frontier AI tools

403(b) retirement plans

Visa sponsorship

Resumo da vaga

Astera Institute is seeking a full-time Senior Scientist, Ensemble-Function Mapping to lead a computational team that turns conformational ensembles into predictions of protein function. This growing team will develop methods that connect ensembles to allosteric coupling, catalytic efficiency, and binding specificity, and build the platforms and pipelines that test which structural data matter most.

This position reports to the Scientific Program Director.

Qualificações

• PhD in a relevant area with at least 4 years of work experience.
• Experience managing a team of scientists.
• Background in computational biophysics linking structure or dynamics to function.
• Experience with machine learning approaches that link protein structure to function.
• Experience with experimental structural data (X-ray, EM, NMR, HDX-MS).
• Ability to communicate findings clearly with modelers, experimentalists, and collaborators.
• Nice to have: knowledge of multiple experimental structural biology methods.
• Nice to have: fluency in the mechanistic literature on allostery, conformational selection, and binding specificity.

Responsabilidades

• Lead Prism's research connecting conformational ensembles to function. Direct the scientific vision to predict and explain allosteric coupling, catalytic efficiency, and binding specificity, and drive that work toward high-impact findings.
• Manage and mentor a team of scientists and recruit additional hires with expertise in machine learning and statistical mechanics.
• Work with the Scientific Program Director to determine strategy and prioritization of approaches, systems, and science within your team.
• Partner with Prism's modeling and encoding team, alongside the Scientific Program Director, to ensure cohesion across the project.
• Build platforms and analysis pipelines that measure how different types of structural data, and the ensemble models derived from them, change functional predictions. Validate them on well-chosen test cases.

Conhecimentos

Team leadership

Computational biophysics

Machine learning

Data analysis

Scientific communication

Formação

PhD in a relevant area

Descrição da vaga

Astera Institute is seeking a full-time Senior Scientist, Ensemble-Function Mapping to lead a computational team that turns conformational ensembles into predictions of protein function. This growing team will develop methods that connect ensembles to allosteric coupling, catalytic efficiency, and binding specificity, and build the platforms and pipelines that test which structural data matter most.

This position reports to the Scientific Program Director.