Principal Scientist, Structural Biology — Protein Dynamics

Genentech; South San Francisco (CA); On-site; USD 151,000 - 280,000; Full time

Benefits offered by this job

Relocation assistance

Comprehensive benefits

Job summary

Genentech in South San Francisco, CA, invites a Principal Scientist in Structural Biology to lead cross-functional efforts integrating cryoEM, X-ray crystallography and computational modeling to reveal protein dynamics and ligand interactions. You will guide discovery teams, design constructs, and translate insights into drug discovery strategies.

The role emphasizes mentorship, collaboration, and technical excellence in a highly interdisciplinary environment with state-of-the-art resources.

Qualifications

• Ph.D. or equivalent in Biochemistry, Structural Biology, Biophysics, Computational Biology, or a related field.
• Minimum 3 years of post-doctoral experience in industry, academia or a research organization.
• Expertise in molecular modeling and dynamics, with biomolecular structure determination experience.

Responsibilities

• Lead structural biology strategy and execution within multi-disciplinary drug discovery teams.
• Oversee protein construct design, expression, purification, and high-resolution structure determination.
• Solve structures of target complexes bound by small molecules, peptides or antibodies.
• Utilize computational and experimental data to characterize protein dynamics.
• Mentor colleagues and develop workflows or training materials.

Skills

Protein dynamics

CryoEM

X-ray crystallography

Molecular dynamics

Ensemble modeling

Leadership

Mentorship

Education

Ph.D. in Biochemistry/Structural Biology/Biophysics/Computational Biology

Tools

Computational modeling tools

Job description

Genentech in South San Francisco, CA, invites a Principal Scientist in Structural Biology to lead cross-functional efforts integrating cryoEM, X-ray crystallography and computational modeling to reveal protein dynamics and ligand interactions. You will guide discovery teams, design constructs, and translate insights into drug discovery strategies.

The role emphasizes mentorship, collaboration, and technical excellence in a highly interdisciplinary environment with state-of-the-art resources.