Lead Scientist, Protein Ensemble-to-Function Mapping

Astera Institute; California; Presencial; USD 200.000 - 250.000; Tempo integral

Benefícios oferecidos por esta vaga

Health insurance

Daily lunch

AI tools licenses

403(b) retirement plan

Flexible PTO

Parental leave

Commuter benefits

FSAs

Visa sponsorship

Resumo da vaga

The Astera Institute in Emeryville, CA seeks a Senior Scientist, Ensemble-Function Mapping to lead a computational team turning conformational ensembles into predictions of protein function. You will develop methods linking ensembles to allosteric coupling, catalytic efficiency, and binding specificity, and build platforms to test which structural data matter.

We value a PhD plus 4+ years, experience managing scientists, and a track record in computational biophysics and machine learning.

Qualificações

• PhD in a relevant area with 4+ years work experience.
• Experience leading a scientific team.
• Background in computational biophysics linking structure to function.
• Experience applying machine learning to protein structure-function problems.
• Experience with at least one experimental structural data type (X-ray/EM/NMR/HDX-MS).
• Execution-forward approach and results-driven mindset.
• Ability to clearly communicate with modelers, experimentalists and collaborators.
• Nice to have: knowledge of multiple experimental methods and literature on allostery.

Responsabilidades

• Lead Prism research linking ensembles to function and drive high-impact findings.
• Manage and mentor a team of scientists and recruit new experts in ML and stat mech.
• Set strategy with the Scientific Program Director and prioritize approaches.
• Collaborate with modeling/encoding teams to ensure project cohesion.
• Build pipelines to measure how data and ensemble models affect functional predictions.

Conhecimentos

PhD + 4+ years experience

Team leadership

Computational biophysics

Machine learning

Experimental structural data (X-ray,EM

Execution-forward

Communication with researchers

Multiple structural biology methods

Formação

PhD in a relevant area

Ferramentas

X-ray

EM

NMR

HDX-MS

Descrição da vaga

The Astera Institute in Emeryville, CA seeks a Senior Scientist, Ensemble-Function Mapping to lead a computational team turning conformational ensembles into predictions of protein function. You will develop methods linking ensembles to allosteric coupling, catalytic efficiency, and binding specificity, and build platforms to test which structural data matter.

We value a PhD plus 4+ years, experience managing scientists, and a track record in computational biophysics and machine learning.