Senior Scientist: Oligonucleotide Synthesis & Bioconjugation

Autonomous Therapeutics; Oregon; On-site; USD 120,000 - 190,000; Full time

Job summary

Autonomous Therapeutics is seeking a highly accomplished synthetic chemist to advance next-generation oligonucleotide medicines for delivery beyond the liver. The role spans solid-phase synthesis, novel RNA/DNA chemistries, and delivery-enabling bioconjugation, with potential focus on oligos, ligands, linkers, or conjugates.

You will join a team of 25 chemists and biologists at a premier R&D facility near Washington, D.C.

Qualifications

• PhD in Chemistry, Materials Science, or related field.
• 5+ years of relevant R&D experience.
• Experience with oligonucleotide synthesis or bioconjugation.

Responsibilities

• Develop next-generation oligonucleotide medicines designed for delivery beyond the liver.
• Bridge solid-phase synthesis with bioconjugation and delivery optimization.
• Collaborate with multidisciplinary teams to advance candidate molecules.

Skills

Solid-Phase Synthesis

Bioconjugation

Oligonucleotide Chemistry

Analytical Chemistry

Research & Development

Education

PhD in Chemistry

Tools

LC-MS

HPLC

Synthesis Equipment

Job description

Autonomous Therapeutics is seeking a highly accomplished synthetic chemist to advance next-generation oligonucleotide medicines for delivery beyond the liver. The role spans solid-phase synthesis, novel RNA/DNA chemistries, and delivery-enabling bioconjugation, with potential focus on oligos, ligands, linkers, or conjugates.

You will join a team of 25 chemists and biologists at a premier R&D facility near Washington, D.C.