Oligonucleotide Scientist

R&D Partners; South San Francisco (CA); On-site; USD 60,000 - 65,000; Full time

Benefits offered by this job

Medical insurance

401k

EAP

Disability insurance

Weekly payroll

Timecard approval

Job summary

R&D Partners is seeking an Oligonucleotide Scientist to join a biotechnology client’s Protein Sciences department in South San Francisco, CA. This 12-month contract role focuses on oligonucleotide discovery and synthesis to support an RNAi biology program and other therapeutics efforts.

The candidate will work in a collaborative chemistry team, contribute to literature reviews, and help deliver accelerated progression of oligonucleotide compounds through preclinical stages.

Qualifications

• BS/MS in Organic Chemistry or related discipline.
• Hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, purification and characterization using HPLC and MS.

Responsibilities

• Work in an oligonucleotide therapeutic drug discovery lab interfacing across neuroscience, immunology and oncology.
• Perform literature reviews and execute nucleic acid chemistry plans; coordinate data.
• Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
• Maintain lab productivity to meet timelines for in vitro and in vivo studies.
• Collaborate with scientists to maintain lab equipment (oligo synthesizers, HPLC, desalting units).
• Support development of comprehensive therapeutic discovery strategy across therapeutic areas.

Skills

Oligonucleotide synthesis

Automated oligo synthesizers

HPLC

Mass spectrometry

RNAi therapeutics

Communication

Education

BS/MS in Organic Chemistry

Tools

Oligo synthesizers

HPLC

Desalting units

Mass spectrometry

Job description

We are hiring a Oligonucleotide Scientist to join our biotechnology client's Protein Sciences department. We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group. Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.

This is a 12-month contract position in South San Francisco, CA.

Responsibilities

• The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy.
• Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.
• Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units.
• Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.
• Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
• Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.

Qualifications

• BS/MS in Organic Chemistry or related discipline.
• Must have hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry.
• The pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.
• A good understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action is preferred.
• Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation is desirable.
• Good communication and interpersonal skills are essential and will be evaluated during the interview process.
• The ideal candidate should be highly motivated and have strong problem-solving, analytical, communication and organizational skills.

Pay

• $43.28-$47.33/hr

Why Choose R&D Partners?

As an employee, you have access to a comprehensive benefits package including:

• Medical insurance – PPO, HMO & HSA
• 401k plan
• Employee Assistance Program
• Long-term disability
• Weekly payroll
• Online timecard approval

R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.

R&D Partners is an equal-opportunity employer.