Senior Scientist, LNP Process Development & MS&T

Nashoba Valley Chamber of Commerce; Harvard (MA); On-site; USD 154,000 - 186,000; Full time

Job summary

Bristol Myers Squibb in Cambridge, MA, is seeking a Principal Scientist, LNP Process Development & MS&T to lead bulk drug product strategies across preclinical to early clinical development. You will drive tech transfer to clinical production, and provide hands‑on scientific leadership in a GMP setting.

The role emphasizes mentorship of scientists, collaboration with internal and external partners, and advancing scalable processes. Some travel may be required to support programs and site teams.

Qualifications

• MS in Bio/Chemical Engineering, Bio/Chemistry, or related field with 8+ years or PhD with 3+ years of experience.
• Expertise with lipid nanoparticle formation and conjugation reactions.
• Experience with tangential flow filtration operations and DoE concepts.
• Experience in clinical manufacturing and cGMP environments.
• Strong written and oral communication; leadership of complex projects.

Responsibilities

• Lead tech transfer from nonclinical to clinical production sites.
• Provide strategic oversight of process development and manufacturability.
• Apply high throughput approaches to mitigate risks in programs.
• Represent SBPD in cross-functional CMC teams.

Skills

LNP formation

Conjugation reactions

Tangential flow filtration

DoE familiarity

Process analytics

DLS

Encapsulation efficiency

Clinical manufacturing experience

cGMP knowledge

Communication skills

Project leadership

Mentoring

GMP experience

Nucleic acid chemistry

Lipid chemistry

Biology knowledge

Education

MS in Bio/Chemical Engineering or related field with 8+ years | PhD with 3+ years

Tools

None listed

Job description

Bristol Myers Squibb in Cambridge, MA, is seeking a Principal Scientist, LNP Process Development & MS&T to lead bulk drug product strategies across preclinical to early clinical development. You will drive tech transfer to clinical production, and provide hands‑on scientific leadership in a GMP setting.

The role emphasizes mentorship of scientists, collaboration with internal and external partners, and advancing scalable processes. Some travel may be required to support programs and site teams.